Author Of 1 Presentation
HIGH MOBILITY GROUP BOX-1 PROTEIN IN PRETERM NEONATES WITH SEPTIC SHOCK: A PROSPECTIVE CASE-MATCHED COHORT STUDY
Abstract
Background
Sepsis and septic shock is one of the major causes for neonatal mortality. Damage Associated Molecular Pattern like High Mobility Group Box-1 (HMGB-1) protein play an important role in the progression of sepsis
Objectives
To compare HMGB1 levels in preterm neonates of ≤ 34 weeks’ gestation with septic shock with gestation and postnatal age matched controls without sepsis
Methods
Preterm neonates of ≤ 34 weeks’ gestation with septic shock were included.Exclusion: Intraventricular hemorrhage (≤ grade 3), severe birth asphyxia and moribund neonates. Primary outcome: HMGB1 level at onset of septic shock. HMGB1 levels were measured within 2 hours of onset of septic shock. Level of sickness at enrolment was assessed by score for neonatal acute physiology-II. All neonates were followed till 7 days from enrolment.
Results
Mean (SD) gestation and birth weight of neonates with septic shock were 30±2.7 weeks and 1192±409g respectively and were comparable with controls. Mean (SD) HMGB-1 levels was higher in neonates with septic shock in comparison to controls [10.95 (7.13) versus 8.98 (7.6); MD (95% C.I): 1.97(-2.23,6.17), p=0.065]. Mean (SD) HMGB1 levels were significantly different between neonates with septic shock, sepsis without shock and no sepsis [10.95 (7.13) versus 12.3 (9.2) versus 9.5 (7.8); Friedman’s p=0.009].
Conclusion
A trend towards higher HMGB-1 levels was observed in neonates with septic shock and sepsis without shock in comparison to neonates without sepsis. Larger, multicentric studies are required to study the role of this molecule in progression of neonatal sepsis