Author Of 2 Presentations
ANTENATAL AND POSTNATAL PREDICTORS OF BRONCHOPULMONARY DYSPLASIA: A SINGLE-CENTER EXPERIENCE
Abstract
Background
Bronchopulmonary dysplasia (BPD) is the chronic lung disorder of preterm infants characterized by multifactorial etiology. Despite the biggest role of genetic susceptibility, several studies were conducted to search for contributing factors.
Objectives
To reveal the antenatal and postnatal factors linked with BPD in a single-center cohort of very preterm infants.
Methods
We carried out this retrospective study in a single-center cohort between January 2014 and December 2018. Preterm infants, < 32 gestational weeks of age and < 1500 g with the diagnosis of moderate/severe BPD were included. All ante-, peri and neonatal data possibly regarding BPD were recorded.
Results
Data of 626 infants were analyzed. Mean gestational ages and birth weight of the whole cohort were 28±1.4 weeks and 1084±225 grams respectively. Of those ninety seven (15.4%) were diagnosed as moderate/severe BPD. Infants with BPD had significantly lower gestational age and birth weight as compared to non-BPD group (27±1.5 weeks and 933±201 grams respectively-p<0.05). All factors significant for moderate/severe BPD in the univariate analysis were included in the logistic regression model. Advanced resuscitation in the delivery room (OR 2.64, Cl [1.57-4.4], low gestational age (OR 0.80, Cl [0.67-0.95]), hemodynamically significant patent ductus arteriosus (OR 1.78, Cl [1.05-3.03]) and late full oral feeding (OR 1.05, Cl [1.02-1.08]) were linked with a higher rate of moderate/severe BPD.
Conclusion
We demonstrated that day of full oral feeding is associated with BPD. Despite the knowledge about the oral feeding problems in preterm infants with BPD, it is unclear whether early oral feeding attempts improve respiratory adverse outcomes.
DOES EARLY POSTNATAL WEIGHT GAIN PREDICT BRONCHOPULMONARY DYSPLASIA?
Abstract
Background
Postnatal growth failure is frequently encountered in infants with bronchopulmonary dysplasia (BPD).
Objectives
To investigate the predictive role of early weekly postnatal weight gain on BPD in preterm infants.
Methods
We performed this retrospective study in a single-center cohort between January 2014 and January 2018. Preterm infants, < 32 gestational weeks of age and < 1500 g with the diagnosis of moderate/severe BPD were included. We assessed the weight gain of the preterm infants weekly during the first 4 weeks of life, then at sixth and eighth weeks. Data about feeding characteristics and weight gain regarding BPD were recorded. Univariate and multivariate logistic regression analyses were performed including all confounding factors.
Results
Data of 474 infants were analyzed. Mean gestational ages and birth weight of the whole cohort were 28.6±1.5 weeks and 1135±227 grams respectively. Of those, eighty-one (17%) were diagnosed as moderate/severe BPD. Infants with BPD had significantly lower gestational age and birth weight as compared to non-BPD group (27±1.5 weeks and 950±207 grams respectively-p<0.05). In the univariate analysis, postnatal weekly weight gain during the first 4 weeks of life was less than non-BPD group (p<0.05). In the logistic regression analysis; lower weight gain in the fourth week of life was associated with higher rate of moderate/severe BPD ((OR 0.89, Cl [0.83-0.95]).
Conclusion
Despite the knowledge of unfavourable effect of poor weight gain on bronchopulmonary dysplasia, there is limited data about exact timing. We demonstrated that poor weight gain during the fourth week of life was an independent risk factor for BPD.