PD151 - MRI BRAIN FINDINGS AND LIKELIHOOD OF DEVELOPING SEIZURES IN INFANTS WITH CONGENITAL CMV (ID 1380)
Abstract
Backgrounds:
Children born with congenital CMV (cCMV) have an increased risk of brain injury and of developing seizures. More severe changes on imaging are associated with a poor prognosis. The aim of this study is to identify the particular imaging features and value of a scoring system of baseline neonatal brain MRIs in predicting the likelihood of developing seizures.
Methods
Records were reviewed for 155 patients referred with cCMV between April 2012 and July 2021. Patients were excluded if they did not have cCMV, were over 2 years old at time of diagnosis, or did not have an MRI scan available for review.
Each MRI was assessed by three neuroradiologists and given a score of 0, 1, 2, or 3 for normal, structural abnormality alone, white matter abnormality alone, white matter abnormality plus structural lesion, respectively.
Results:
| No seizure | Seizure | |||||
| Number | 63 | 8 | ||||
| Occipital Head Circumference (median Z score) | -1.645 | -2.554 | ||||
| Birth weight (median Z score) | -1.603 | -1.594 | ||||
| Gestation (median weeks) | 38 | 32 | ||||
| Score_MR | ||||||
| 0 | 21 (33.33%) | 1 (12.5%) | ||||
| 1 | 7 (11.11%) | 0 (0%) | ||||
| 2 | 10 (15.87%) | 1 (12.5%) | ||||
| 3 | 25 (39.68%) | 6 (75%) | ||||
| Cortical malformation | 12 (19.05%) | 6 (85%) | ||||
| Cysts | 25 (39.68%) | 6 (85%) | ||||
| Calcification | 29 (46.03%) | 4 (50%) | ||||
Conclusions/Learning Points:
A higher brain MRI score, representing more severe abnormalities, was associated with a greater likelihood of seizures.
3.57% scoring 0-1 developed seizures, 16.67% scoring 2-3 did, highlighting that the presence of cortical malformation, calcification and cysts increase the likelihood of seizures.
