EP170 - NEONATES BORN TO MOTHERS INFECTED WITH SYPHILIS: A RETROSPECTIVE 7 -YEAR STUDY (ID 1314)
Abstract
Title of Case:
NEONATES BORN TO MOTHERS INFECTED WITH SYPHILIS: A RETROSPECTIVE 7 YEAR STUDY
Background:
Congenital syphilis (CS) still represents a worldwide public health problem despite preventive strategies.It can lead to high neonatal morbidity and mortality if left untreated.The risk of transmission in relation to the maternal stage of infection is highest during untreated primary or secondary syphilis.
Case Presentation Summary:
A retrospective cohort study was performed including neonates born to mothers with reactive serologic test for syphilis during pregnancy from January 2015 until December 2021.
Learning Points/Discussion:
A total of 4 newborns (3/4 males, median gestation age of 36weeks, mean birth weight 2710gr) were investigated for CS.Mothers were all diagnosed with latent infection but only one had received appropriate therapy.One neonate (1/4, 25%) had positive serum non-treponemal titers, less than fourfold of the maternal titer. None of the neonates had positive treponemal IgM antibodies.Further evaluation was performed with complete blood count (4/4), liver function tests (4/4), cerebrospinal fluid analysis (CSF) (3/4), long bone radiographs (2/4), cranial ultrasound (4/4), ophthalmologic examination (3/4) and auditory brainstem responses (3/4).Most neonates (3/4, 75%) had no clinical or laboratory manifestations of CS. One neonate had rhinitis and CSF pleiocytosis.Neonates with possible CS were treated with intravenous crystalline penicillin G for 10 days (3/4, 75%).The neonate born to mother with adequately treated syphilis was treated with intramuscular benzathine penicillin G in a single dose. After discharge, all infants were followed with repeat non-treponemal titers until achieving non-reactive titers.
CS can be effectively prevented by prenatal serologic screening of mothers and timely treatment of infected ones.Neonates born to mothers with reactive syphilis serology during pregnancy should be timely diagnosed and treated with appropriate antibiotics started early after delivery.
