Serena Salomè (Italy)
University of Naples “Federico II”, Naples, Italy, Department of Translational Medical Sciences, Division of NeonatologyPresenter of 1 Presentation
A CUSTOMIZED SEROLOGICAL FOLLOW UP FOR NEONATES EXPOSED TO TOXOPLASMA GONDII IN UTERO (ID 871)
Abstract
Background
Toxoplasma Gondii is a parasite with a transplacental passage. Evaluation of newborns exposed to Toxoplasmosis in pregnancy includes ophthalmologic and auditory tests, neurologic examination at birth and serological evaluation until 12 months, to assess the possibility of congenital infection. The aim of this study is to evaluate serological testing timeline in neonates exposed to Toxoplasmosis in pregnancy.
Methods
This is a single center, population-based cohort study of neonates referred for prenatal exposure to Toxoplasmosis from 2014 to 2019. Neonates underwent clinical, laboratory and instrumental investigation for at least 12 months as recommended by national guidelines. A total of 670 neonates were referred to the Perinatal Infection Unit of the University Federico II of Naples. Six hundred thirty-six (95%) completed the serological follow up until twelve months.
Results
Specific IgG antibodies negativization occurred in 628 (98.7%) within 5 months. At 9 and 12 months, all neonates had negative IgG. Initial neonatal IgG antibody titer =300 UI/ml was associated with time to negativization (241.5±38.2 days when above threshold vs. 137.1±42.6 days when below it; p<0.0001). Initial maternal IgG antibody titer = 300 UI/ml was also associated to time to negativization in the infant (196.1±35.7 days above the cut off vs 135.4±42.6 days below it; p<0.0001). Specific antibody negativization was irreversible in all patients.
Conclusions
Initial maternal and neonatal anti Toxoplasma IgG titers are significantly associated with the time to antibody negativization. These biomarkers can be useful to customize the follow up duration and avoid unnecessary blood drawing.