All times are listed in CEST (Central European Summer Time)
- David SP Tan (Singapore, Singapore)
- Ana Oaknin (Barcelona, Spain)
LBA36 - Efficacy and safety of senaparib as maintenance treatment in patients with newly diagnosed advanced ovarian cancer (FLAMES study): A randomized, double-blind, placebo-controlled, phase III trial
- Xiaohua Wu (Shanghai, China)
Abstract
Background
Ovarian cancer (OC) is one of the most lethal gynecologic cancers. Approximately 85% of newly diagnosed advanced OC may experience a relapse after the first line (1L) platinum-based chemotherapy. PARP inhibitors are recommended as maintenance therapy to prolong the benefit of platinum. Senaparib (IMP4297) is a novel, highly potency PARP inhibitor. The phase 3 study FLAMES is to investigate the efficacy and safety of Senaparib in Chinese patients (pts) with newly diagnosed advanced OC as 1L maintenance therapy.
Methods
Eligible pts had newly diagnosed, FIGO stage III–IV, high-grade serous or endometrioid OC, who have completed 1L platinum-based chemotherapy with complete response (CR) or partial response (PR). Pts were randomized (2:1) to receive senaparib (Sena) or placebo (PBO) 100 mg/day orally, stratified by CR/PR and BRCA mutation positive/negative. Primary endpoint was progression-free survival (PFS ) evaluated by blinded independent central review (BICR) according to RECIST v1.1.
Results
404 pts were randomized. As of 16 Mar. 2023, 270 and 133 pts received Sena and PBO with a median follow-up of 22.4 and 22.2 months, respectively. Primary analysis showed Sena significantly improved PFS over placebo (HR 0.43, 95% CI 0.32-0.58, P < 0.0001), irrespective of BRCA mutation status ( HR 0.43, P < 0.01). Secondary endpoints support the primary analysis (Table). Incidence rates of grade ≥3 adverse events (AEs) were 66.3 % vs 20.3%, AEs leading to dose reduction 63.3 % vs 6.0% and discontinuation 4.4 % vs 0% in Sena and PBO arm. No AE leading to death. BICR, blinded independent central review; INVR, investigator review; HR, hazard ratio; NR, not reached; PFS, progression-free survival; BRCA +, breast cancer susceptibility gene (BRCA) mutation positive; BRCA -, BRCA mutation negative; TFST, time to first subsequent therapy or death; m, month
Senaparib (n=271), m Placebo (n=133), m HR (95%CI), P value PFS (BICR) NR 13.6 0.43 (0.32-0.58) P < 0.0001 PFS (BICR) BRCA + NR 15.6 0.43 (0.24-0.76) P = 0.0026 PFS (BICR) BRCA- NR 12.9 0.43 (0.30-0.61) P < 0.0001 PFS (INVR) NR 11.1 0.43 (0.32-0.57) P < 0.0001 PFS (INVR) BRCA + NR 11.1 0.33 (0.20-0.56) P < 0.0001 PFS (INVR) BRCA- NR 11.1 0.48 (0.34-0.67) P < 0.0001 TFST NR 14.4 0.44 (0.33-0.59) P < 0.0001
Conclusions
1L maintenance Senaparib led to an unprecedented reduction in the risk of progression or death versus placebo in OC, regardless of biomarker status. Senaparib was well tolerated, no new safety signals were identified.
Clinical trial identification
NCT04169997.
Legal entity responsible for the study
IMPACT Therapeutics, Inc.
Funding
IMPACT Therapeutics, Inc.
Disclosure
All authors have declared no conflicts of interest.
LBA37 - Atezolizumab (atezo) combined with platinum-based chemotherapy (CT) and maintenance niraparib for recurrent ovarian cancer (rOC) with a platinum-free interval (TFIp) >6 months: Primary analysis of the double-blind placebo (pbo)-controlled ENGOT-Ov41/GEICO 69-O/ANITA phase III trial
- Antonio Gonzalez Martin (Madrid, Spain)
Abstract
Background
Standard therapy for late-relapsing (TFIp >6 mo) rOC includes PARPi maintenance if disease responds to platinum-based CT. ANITA (NCT03598270) is the first-reported phase 3 trial evaluating atezo with platinum-based CT and maintenance PARPi in late-relapsing rOC.
Methods
Eligible pts had measurable high-grade serous, endometrioid or undifferentiated rOC, ≤2 prior CT lines (most recent including platinum) and TFIp >6 mo. Prior PARPi for rOC and/or prior immune checkpoint inhibitor were prohibited. Pts were stratified by carboplatin (carbo) doublet (paclitaxel, gemcitabine or pegylated liposomal doxorubicin [PLD]), TFIp (6–12 vs >12 mo),
Results
Between Nov 2018 and Jan 2022, 417 pts were randomised (14% aUnadjusted estimate.
PFS Pbo + CT → pbo + niraparib (n=209) Atezo + CT → atezo + niraparib (n=208) All pts Events, n (%) 174 (83) 170 (82) Hazard ratio (95% CI) 0.89 (0.71–1.10); p=0.28 Median, mo (95% CI) 10.1 (9.2–11.2) 11.2 (10.1–12.1) PD-L1-positive subgroup Events, n/N (%) 60/73 (82) 61/76 (80) Hazard ratio (95% CI) 0.87 (0.61–1.25)a Median, mo (95% CI) 11.1 (9.7–12.7) 12.8 (10.2–15.4) PD-L1-negative subgroup Events, n/N (%) 92/112 (82) 97/117 (83) Hazard ratio (95% CI) 0.93 (0.70–1.24)a Median, mo (95% CI) 9.2 (8.3–11.1) 10.5 (9.2–11.8)
Conclusions
Combining atezo with CT and maintenance niraparib for late-relapsing rOC did not significantly improve PFS or ORR.
Clinical trial identification
NCT03598270, EudraCT 2018-000366-11.
Editorial acknowledgement
Jennifer Kelly (Medi-Kelsey Ltd).
Legal entity responsible for the study
GEICO.
Funding
F. Hoffmann-La Roche Ltd and GSK.
Disclosure
A. Gonzalez Martin: Financial Interests, Personal, Advisory Board: Amgen, AstraZeneca, Clovis, GSK, Genmab, Alkermes, Sutro, Roche, Sotio, PharmaMar, Oncoinvent, Novartis, Mersana, MSD, Macrogenics, Eisai, Inmunogen, Regeneron, HederaDx, Illumina; Financial Interests, Personal, Invited Speaker: GSK, AstraZeneca, Clovis, Roche, Novocure, MSD, Takeda, Zaylab; Financial Interests, Institutional, Coordinating PI, PI of ANITA trial: GSK, Roche; Financial Interests, Personal, Steering Committee Member, Member of ENGOT ov43-SC: MSD; Financial Interests, Institutional, Coordinating PI, ENGOT PI of EPIK-O trial: Novartis; Financial Interests, Institutional, Coordinating PI, ENGOT PI of AVB-500 phase III trial: Aravive. F. Heitz: Financial Interests, Personal, Advisory Board: Roche, AstraZeneca, GSK, NovoCure; Financial Interests, Personal, Invited Speaker: AstraZenecA, GSK. N. Colombo: Financial Interests, Personal, Advisory Board, Various: Roche, AstraZeneca, MSD/Merck, Clovis Oncology, GSK, Immunogen, Mersana; Financial Interests, Personal, Invited Speaker, Congress, Symposia, Lectures: AstraZeneca; Financial Interests, Personal, Advisory Board, Lectures: Eisai; Financial Interests, Personal, Advisory Board, Advisory role: Nuvation Bio, Pieris; Financial Interests, Personal, Advisory Board, Advisory Role: Onxerna; Financial Interests, Personal, Invited Speaker: MSD/Merck; Financial Interests, Personal, Invited Speaker, Speaker: GSK; Financial Interests, Institutional, Research Grant: AstraZeneca, Roche, GSK; Non-Financial Interests, Other, Steering Committee, member Clinical Guidelines: ESMO; Non-Financial Interests, Leadership Role, Chair, Scientific Committee: ACTO (Alleanza contro il tumore ovarico). T. Van Gorp: Financial Interests, Institutional, Advisory Board, Jan-2021 until 09-2022: AstraZeneca; Financial Interests, Institutional, Other, Travel costs: AstraZeneca, GSK, MSD/Merck, PharmaMar; Financial Interests, Institutional, Advisory Board, Jan-2021: Eisai; Financial Interests, Institutional, Advisory Board, May-2021 until present: GSK; Financial Interests, Institutional, Invited Speaker, Apr 2022: GSK; Financial Interests, Institutional, Advisory Board, Apr-2021 until present: MSD; Financial Interests, Institutional, Advisory Board, Feb-2021: OncXerna Therapeutics; Financial Interests, Institutional, Advisory Board, Feb 2023 until present: Tubulis; Financial Interests, Institutional, Advisory Board: ImmunoGen; Financial Interests, Institutional, Research Grant, Oct-2020 until Oct-2021: Amgen; Financial Interests, Institutional, Research Grant, Oct-2020 until Oct-2022: Roche; Financial Interests, Institutional, Research Grant, Jan 2022 until Mar 2023: AstraZeneca. A. Oaknin: Financial Interests, Personal, Advisory Board: Agenus, AstraZeneca, Clovis Oncology, Corcept Therapeutics, Deciphera Pharmaceuticals, EMD Serono, Eisai, F. Hoffmann-La Roche, GSK, Genmab, Immunogen, Itheos, Merck Sharps & Dohme de España, SA, Mersana Therapeutics, Novocure, OncXerna Therapeutics, Inc, PharmaMar, Regeneron, Sattucklabs, Seagen, Sutro Biopharma, Exelisis; Financial Interests, Personal, Other, Travel and accomodation: AstraZeneca, PharmaMar, Roche; Financial Interests, Institutional, Funding: Amgen, AbbVie Deutschland, Advaxis Inc., Aeterna Zentaris, Aprea Therapeutics AB, Regeneron Pharmaceuticals, Clovis Oncology Inc, EISAI limited LTD, F. Hoffmann –La Roche LTD, Immunogen Inc, Merck, Sharp & Dohme de España SA, Millennium Pharmaceuticals Inc, PharmaMar SA, Tesaro Inc., Bristol Myers Squibb; Non-Financial Interests, Leadership Role, on behalf of GEICO: GCIG; Non-Financial Interests, Officer, Chair of Gynaecological Track ESMO 2019. Scientific Track Member Gynaecological Cancers ESMO 2018, ESMO 2020, ESMO 2022. Member of Gynaecological Cancers Faculty and Subject Editor Gyn ESMO Guidelines.: ESMO; Non-Financial Interests, Leadership Role, ESMO GYN Co-Chair 2023 - 2025: ESMO; Non-Financial Interests, Leadership Role, Chair de Cervix Committee. 2022-2024: GCIG; Non-Financial Interests, Member: ESMO, ASCO, GCIG, SEOM, GOG. A. Leary: Financial Interests, Personal, Advisory Board: Zentalis; Financial Interests, Personal, Invited Speaker, Educational: GSK, Medscape; Financial Interests, Personal, Writing Engagement, Educational: Onko+; Financial Interests, Institutional, Other, Steering committee: MSD; Financial Interests, Institutional, Advisory Board: GSK, AZ, Clovis, Ability Pharma, MSD, Merck Serono, Apmonia, Blueprint; Financial Interests, Institutional, Invited Speaker, Educational: Kephren publishing; Financial Interests, Institutional, Other, Consultancy: Orion; Financial Interests, Institutional, Invited Speaker: AZ, Clovis; Financial Interests, Personal, Other, Consultancy: GLG; Financial Interests, Institutional, Other, consultancy: Owkin; Financial Interests, Institutional, Research Grant, PI translational research: ARCAGY-GINECO, Sanofi, AZ; Financial Interests, Institutional, Funding, CI clinical trial: AZ; Financial Interests, Institutional, Research Grant, Int CI clinical trial: OSE immuno; Financial Interests, Institutional, Funding, PI clinical trial: Agenus, BMS, Iovance, GSK; Financial Interests, Institutional, Funding, PI 5 clinical trials: Roche; Financial Interests, Institutional, Funding, PI 2 clinical trials: AZ; Financial Interests, Institutional, Funding, PI 3 clinical trials and steering committee: MSD; Non-Financial Interests, Institutional, Other, Academic research project: Owkin, LXRepair; Non-Financial Interests, Personal, Proprietary Information, IDMC member: Clovis; Non-Financial Interests, Personal, Proprietary Information, IDMC chair: Pfizer; Non-Financial Interests, Member: GCIG. L. Gaba Garcia: Financial Interests, Personal, Advisory Board: GSK, PharmaMar, AstraZeneca, AstraZeneca, MSD, Clovis Oncology; Financial Interests, Personal, Invited Speaker: GSK, MSD, Clovis Oncology. C. Lebreton: Financial Interests, Personal, Advisory Board: GSK, GSK, MSD, EISAI, CLOVIS oncology. M. Romeo Marin: Financial Interests, Personal, Advisory Board, Educational purposes: MSD; Financial Interests, Personal, Advisory Board: GSK; Financial Interests, Personal, Invited Speaker: AZ; Financial Interests, Institutional, Local PI: Tesaro, MSD, Roche, IMNG. A. Redondo: Financial Interests, Personal, Invited Speaker: MSD, AstraZeneca, GSK, Clovis, PharmaMar; Financial Interests, Personal, Advisory Board: MSD, AstraZeneca, GSK, Clovis, PharmaMar; Financial Interests, Institutional, Local PI: Roche, Eisai, PharmaMar. M.P. Barretina Ginesta: Financial Interests, Personal, Advisory Board: AstraZeneca, GSK, MSD, EISAI, PharmaMar; Financial Interests, Personal, Invited Speaker: AstraZeneca, GSK, MSD; Financial Interests, Personal, Steering Committee Member: MSD. J.A. Perez Fidalgo: Financial Interests, Personal, Invited Speaker: AstraZeneca, Clovis, GSK, PharmaMar; Financial Interests, Personal, Advisory Board: AstraZeneca, GSK, Clovis, PharmaMar, Roche, Abilify Pharma; Financial Interests, Personal, Full or part-time Employment, Associate Professor: University of Valencia; Financial Interests, Institutional, Research Grant: GSK, PharmaMar; Financial Interests, Institutional, Funding: Novartis, GSK; Financial Interests, Institutional, Coordinating PI: AstraZeneca; Financial Interests, Personal, Steering Committee Member: AstraZeneca, Artios Pharma; Non-Financial Interests, Project Lead, Coordinating PI Phase III trial in breast cancer: Novartis; Non-Financial Interests, Member, Member of the Early Drug Development working group: ENGOT; Non-Financial Interests, Leadership Role, Member of the Executive Committee and Head of the Scientific Committee: GEICO; Non-Financial Interests, Leadership Role, Member of the Executive Commitee and co-coordinator of Uterine Sarcoma Group: GEIS; Non-Financial Interests, Leadership Role, Co-chair Phase 2 group: GCIG; Non-Financial Interests, Member: BIG; Non-Financial Interests, Member, Adolescent and Young Adults working group: SEOM. A. Santaballa Bertran: Financial Interests, Personal, Advisory Board: Clovis, GSK, MSD, Astra; Financial Interests, Personal, Invited Speaker: Clovis, GSK, Astra, MSD. I.L. Ray-Coquard: Financial Interests, Personal, Advisory Board: Roche, GSK, AstraZeneca, Mersana, Deciphera, Amgen, Oxnea, Merck Sereno, Agenus, Novartis, Macrogenics, Clovis, EQRX, Adaptimmune, Esai, SUTRO, BMS, Adaptimmune, Daiichi Sankyo; Financial Interests, Institutional, Other, COLIBRI translational research: BMS; Financial Interests, Institutional, Advisory Board, translational research NEOPREMBROV trial: MSD; Non-Financial Interests, Principal Investigator: PAOLA1; Non-Financial Interests, Other, President: GINECO. F. Selle: Financial Interests, Personal, Invited Speaker: AstraZeneca, MSD, GSK/Tesaro, Eisai; Financial Interests, Personal, Advisory Board: AstraZeneca, MSD, GSK/Tesaro. All other authors have declared no conflicts of interest.
Invited Discussant LBA36 and LBA37
- Charlie Gourley (Edinburgh, United Kingdom)
Q&A
- All Speakers (Lugano, Switzerland)
LBA38 - Pembrolizumab plus chemoradiotherapy for high-risk locally advanced cervical cancer: A randomized, double-blind, phase III ENGOT-cx11/GOG-3047/KEYNOTE-A18 study
- Domenica Lorusso (Rome, Italy)
Abstract
Background
Pembrolizumab (pembro) has shown efficacy in patients (pts) with cervical cancer. The effect of chemoradiotherapy may be enhanced by immunotherapy. ENGOT-cx11/GOG-3047/KEYNOTE-A18(NCT04221945) assessed the efficacy and safety of pembro + concurrent chemoradiotherapy (CCRT) for locally advanced cervical cancer.
Methods
Eligible pts with newly diagnosed, previously untreated, high-risk locally advanced cervical cancer (FIGO 2014 stage IB2-IIB with node-positive disease or stage III-IVA) were randomized 1:1 to receive 5 cycles of pembro 200 mg or pbo Q3W + CCRT, then 15 cycles of pembro 400 mg or pbo Q6W. The CCRT regimen included 5 cycles (with optional 6th dose) of cisplatin 40 mg/m2 Q1W + EBRT then brachytherapy. Pts were stratified by planned EBRT type (intensity-modulated radiotherapy [IMRT] or volumetric-modulated arc therapy [VMAT] vs non-IMRT or non-VMAT), stage at screening (stage IB2-IIB vs III-IVA) and planned total radiotherapy dose. Primary endpoints were PFS per RECIST version 1.1 by investigator and OS.
Results
1060 pts were randomized to pembro + CCRT (n=529) or pbo + CCRT (n=531). At the protocol-specified first interim analysis (January 9, 2023, data cutoff), median follow-up was 17.9 mo (range, 0.9-31.0). Pembro + CCRT showed a statistically significant improvement in PFS vs pbo + CCRT. 24-mo PFS was 67.8% with pembro + CCRT vs 57.3% with pbo + CCRT; median PFS was not reached in either group (HR=0.70 [95% CI, 0.55-0.89; P=0.0020]); results were consistent across all prespecified subgroups. With only 103 events (42.9% maturity), the addition of pembro to CCRT showed a favorable trend in OS (HR=0.73 [95% CI, 0.49-1.07]); these data have not crossed the boundary of statistical significance. Grade ≥3 TRAE incidence was 67.0% in the pembro + CCRT group and 60.0% in the pbo + CCRT group.
Conclusions
Pembro + CCRT showed a statistically significant and clinically meaningful improvement in PFS and a favorable trend in OS compared with pbo + CCRT in pts with high-risk locally advanced cervical cancer and had a manageable safety profile. These data suggest pembro + CCRT can be considered as a new standard of care for this population.
Clinical trial identification
NCT04221945.
Editorial acknowledgement
Editorial assistance in the writing of the abstract was provided by Christine McCrary Sisk, an employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, U.S.A.
Legal entity responsible for the study
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, U.S.A.
Funding
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, U.S.A.
Disclosure
D. Lorusso: Financial Interests, Personal, Advisory Board, Participation in Advisory Boards and Invited Speaker: GSK, Clovis Oncology, PharmaMar; Financial Interests, Personal, Advisory Board, Participation in Advisory Boards and Invited Speakers: AstraZeneca, MSD; Financial Interests, Personal, Other, Consultancy: PharmaMar, AstraZeneca, Clovis Oncology, GSK, MSD, Immunogen, Genmab, Seagen, Novartis; Financial Interests, Personal, Advisory Board, Invited member of advisory board and invited speaker: Seagen, Immunogen, Genmab; Financial Interests, Personal, Advisory Board, Invited member of advisory board: Oncoinvest, Corcept, Sutro; Financial Interests, Institutional, Funding, Grant for founding academic trials: MSD, Clovis Oncology, GSK, PharmaMar; Financial Interests, Institutional, Coordinating PI, ENGOT trial with institutional support for coordination: Clovis Oncology; Financial Interests, Institutional, Coordinating PI, ENGOT trial with insitutional support for coordination: Genmab, MSD; Financial Interests, Institutional, Funding, Clnical trial/contracted research: AstraZeneca, Clovis Oncology, GSK, MSD, Seagen; Financial Interests, Institutional, Funding, Clinical trials/contracted research: Genmab, Immunogen, Incyte, Novartis, Roche; Non-Financial Interests, Principal Investigator, PI of several trials, no compensation received: GSK; Non-Financial Interests, Principal Investigator, PI of several trials. No personal compensation received: AstraZeneca, genmab; Non-Financial Interests, Principal Investigator, PI in several trials. No personal compensation received: MSD; Non-Financial Interests, Principal Investigator, PI of clinical trial. No personal compensation received: immunogen, Clovis Oncology, roche, Incyte; Non-Financial Interests, Principal Investigator, PI of several trials, no personal compensation received: Novartis; Non-Financial Interests, Principal Investigator, PI of clinical trial, no personal compensation received: Seagen; Non-Financial Interests, Principal Investigator, PI of clinical trials, no personal compensation received: PharmaMar; Non-Financial Interests, Member, Board of Directors: GCIG; Other, Grants for traveling: AstraZeneca, Clovis Oncology, GSK. Y. Xiang: Financial Interests, Institutional, Funding, Study funding: MSD; Financial Interests, Personal, Advisory Role, Member of Scientific Advisory Committee for MK3475-A18 study: MSD. K. Hasegawa: Financial Interests, Personal, Invited Speaker: MSD, AstraZeneca, Takeda, Chugai, Genmab, Kaken, Eisai, Sanofi, GSK; Financial Interests, Personal, Advisory Board: Daiichi Sankyo; Financial Interests, Institutional, Funding, contracted research: MSD, Ono, Daiichi Sankyo, Eisai, Takeda. G. Scambia: Financial Interests, Personal, Invited Speaker, Speaker: Baxter Healthcare, GSK, Intuitive Surgical Inc., AstraZeneca & MSD, Olympus Europa, GSK, AstraZeneca & MSD, Olympus Europa; Financial Interests, Personal, Advisory Board, Trainer: Covidien AG (Medtronic company); Financial Interests, Institutional, Coordinating PI, ‘IsoMSLN’ in Ovarian Cancer and Malignant Pleural Mesothelioma: Kiromic; Financial Interests, Institutional, Coordinating PI, Roll-over study for patients who have completed a previous cancer study with olaparib and who the investigator believes can benefit from continued treatment - ROSY-O: AstraZeneca; Financial Interests, Institutional, Coordinating PI, CATCH-R: Roll-over study to provide continuous access to clinical therapy with rucaparib.: Clovis Oncology; Financial Interests, Institutional, Coordinating PI, Phase 3, multicenter, placebo-controlled clinical study comparing chemo-immunotherapy (paclitaxel-carboplatin-oregovomab) versus chemotherapy (paclitaxel-carboplatin-placebo) in patients with advanced epithelial ovarian, tubal cancer of fallopian or peritoneal (FLORA-5): Oncoquest Pharmaceuticals Inc.; Financial Interests, Institutional, Coordinating PI, Phase 2b randomized, open-label, active comparator, parallel-group, multicenter study designed to evaluate the efficacy and safety of three different doses of the P2X3 receptor antagonist (BAY 1817080) versus placebo and Elagolix 150 mg in women with symptomatic endometriosis: Bayer AG; Financial Interests, Institutional, Coordinating PI, Usability of ITE transducers for sending electric fields for tumor treatment (TTFields): Novocure Ltd; Financial Interests, Institutional, Coordinating PI, Phase III, multicentre, open-label extension trial to evaluate long-term safety and efficacy in patients with advanced cancers currently undergoing treatment or in follow-up in a pembrolizumab trial.: Merck. M.H. Leiva Galves: Financial Interests, Personal, Invited Speaker: AstraZeneca; Financial Interests, Personal and Institutional, Principal Investigator: AstraZeneca, Roche, MSD, BMS. P. Ramos Elias: Financial Interests, Personal, Invited Speaker, Guest speaker at educational events: MSD, Asofarma, Novartis, AstraZeneca; Financial Interests, Personal, Advisory Board, Participation as a local expert on advisory board meetings: Bristol Myers Squibb, Asofarma, AstraZeneca; Financial Interests, Personal, Advisory Board, local expert on advisory board meetings: Pfizer; Financial Interests, Personal and Institutional, Local PI, Fees for conducting clinical studies: MSD, Roche Genentech, Zymeworks. A. Acevedo: Financial Interests, Institutional, Principal Investigator: Merck Sharp & Dohme. J. Vizkeleti: Financial Interests, Institutional, Principal Investigator: Merck & Co., Inc.. A.J.P.D.S. Gomes: Financial Interests, Personal, Invited Speaker: Astellas, Bayer, Janssen, AstraZeneca; Financial Interests, Personal, Advisory Board: Bayer, Janssen. F. Contreras Mejia: Financial Interests, Personal, Invited Speaker: MSD, BMS, GSK, Eli Lillly, AstraZeneca, Novartis; Financial Interests, Personal, Expert Testimony: MSD, Janssen, GSK, Eli Lilly, BMS; Financial Interests, Personal, Other, Meeting and travel support: MSD, Amgen. A. Reiss: Financial Interests, Personal, Advisory Board: MSD Israel. J. Lee: Financial Interests, Personal, Invited Speaker: AstraZeneca, Takeda, MSD, Roche; Financial Interests, Personal, Advisory Board: Eisai, GI Innovation; Financial Interests, Institutional, Local PI: Alkermes, AstraZeneca, BergenBio, Cellid, Clovis Oncology, Eisai, GI Innovation, ImmunoGen, Janssen, Merck, Mersana, MSD, Novartis, OncoQuest, Roche, Seagen, Synthon; Financial Interests, Personal and Institutional, Local PI: Beigene; Financial Interests, Personal, Steering Committee Member: AstraZeneca, OncoQuest, Seagen, ImmunoGen, MSD; Financial Interests, Institutional, Research Grant: ONO, Takeda. F. Zagouri: Financial Interests, Personal, Invited Speaker: AstraZeneca, Daiichi Sankyo, Eli Lilly, Merck, MSD, Novartis, Pfizer, Genesis- Pharma, Roche and Gilead; Financial Interests, Personal, Writing Engagement: AstraZeneca, Daiichi Sankyo, Eli Lilly, Merck, MSD, Novartis, Pfizer, Genesis- Pharma, Roche and Gilead; Financial Interests, Personal, Advisory Board: AstraZeneca, Daiichi Sankyo, Eli Lilly, Merck, MSD, Novartis, Pfizer, Genesis- Pharma, Roche and Gilead; Financial Interests, Institutional, Research Grant: AstraZeneca, Daiichi Sankyo, Eli Lilly, Merck, MSD, Novartis, Pfizer, Genesis- Pharma, Roche and Gilead; Financial Interests, Institutional, Funding: AstraZeneca, Daiichi Sankyo, Eli Lilly, Merck, MSD, Novartis, Pfizer, Genesis- Pharma, Roche and Gilead; Financial Interests, Personal, Principal Investigator: AstraZeneca, Daiichi Sankyo, Eli Lilly, Merck, MSD, Novartis, Pfizer, Genesis- Pharma, Roche and Gilead; Financial Interests, Institutional, Principal Investigator: AstraZeneca, Daiichi Sankyo, Eli Lilly, Merck, MSD, Novartis, Pfizer, Genesis- Pharma, Roche and Gilead; Financial Interests, Institutional, Sponsor/Funding: AstraZeneca, Daiichi Sankyo, Eli Lilly, Merck, MSD, Novartis, Pfizer, Genesis- Pharma, Roche and Gilead; Financial Interests, Personal, Advisory Role: AstraZeneca, Daiichi Sankyo, Eli Lilly, Merck, MSD, Novartis, Pfizer, Genesis- Pharma, Roche and Gilead. K. Li: Financial Interests, Personal, Full or part-time Employment: Merck & Co., Inc.; Financial Interests, Personal, Stocks/Shares: Merck & Co., Inc.. K. Ussui Yamada: Financial Interests, Personal, Full or part-time Employment: Merck & Co., Inc.; Financial Interests, Personal, Stocks/Shares: Merck & Co., Inc.. S. Toker: Financial Interests, Personal, Full or part-time Employment: Merck & Co., Inc.; Financial Interests, Personal, Stocks/Shares: Merck & Co., Inc.. S. Pignata: Financial Interests, Personal, Advisory Board: Roche, AZ, MSD, Clovis, GSK, PharmaMar; Financial Interests, Institutional, Funding: Roche, MSD, Pfizer, AZ. L.R. Duska: Financial Interests, Personal, Advisory Board, Scientific advisory board: Aadi Bioscience; Financial Interests, Personal, Royalties, I write expert content for UpToDate: UpToDate; Financial Interests, Personal, Other, I serve on the Editorial Board: British Journal of Obstetrics and Gynecology; Financial Interests, Institutional, Research Grant, Merck has provided funding for investigator initiated trials to my institution: Merck; Non-Financial Interests, Advisory Role, Acted as an expert advisor for: Merck. All other authors have declared no conflicts of interest.
Invited Discussant LBA38
- Bradley J. Monk (Tucson, United States of America)
Q&A
- All Speakers (Lugano, Switzerland)