The Bogunovic lab focuses on the study of human immunogenetics. We aim to improve understanding of the human immune system by studying: 1) Individuals with rare auto-inflammatory syndromes. 2) Individuals with severe clinical presentations of infectious diseases. 3) Developing broad spectrum antiviral therapeutics. 4) Understanding immune system in Down syndrome. To dissect these phenotypes and develop therapeutics we use genomic, genetic, molecular biology, cellular biology, immunology and clinical tools.