My background and strong research interest have always been revolved around primary immunodeficiency (PID), with particular focus on immune dysregulation disorders. I did part of my training abroad in preeminent centres (USA and UK) and I was involved in studying both clinical and molecular aspects of PID as well as treatment options (i.e. BMT/cellular therapies). This has opened up enormous possibilities for fruitful collaborative research also enhanced by my longstanding involvement in the activities of the European Society for Immunodeficiencies (ESID) since 2006. My clinical and research activity during the past 15 years has been mainly focused on PID, autoimmunity and predisposition to cancer. I have participated to several international and national conferences presenting my research data and also as invited speaker. I currently hold an Associate Professorship position in Pediatrics at University of Florence and I am the head of the Immuno-Hemato-Oncology Unit within the Haem/Onc Department at Meyer Children's Hospital in Florence, Italy.