Oscar Correa-Jimenez, Colombia
Presenter of 1 Presentation
CLINICAL AND RADIOLOGICAL CHARACTERIZATION OF THE RESPIRATORY TRACT COMPROMISE IN PATIENTS WITH PREDOMINANTLY ANTIBODY DEFICIENCY AT A PEDIATRIC REFERENCE CENTER IN BOGOTA-COLOMBIA
Abstract
Background and Aims
Predominantly Antibody Deficiencies (PAD) are the most frequent type of PID. Respiratory comorbidities are common in these patients and contribute to their morbidity and mortality. A better understanding of this condition could help to develop preventive and therapeutic strategies. This study aimed characterizes the respiratory compromise in these patients attended at the biggest Colombian Children’s Hospital.
Methods
We conducted a review of electronic medical records for patients with PID treated at HOMI Fundacion Hospital la Misericordia between 2014-2017 focusing on the respiratory comorbidities that they presented clinically or radiologically at time of PID diagnosis. Patients with PID were identified in our institutional database using ICD-10 codes and categorized following IUIS2017 Phenotypic classification.
Results
A total of 73 patients with PAD were included in this study. The median age (P25-P75) in these patients was 28 months (7.5-52 months) and male/female ratio 25/48. The 78.1% of patients presented at least one episode of pneumonia before the PAD diagnosis, 84.2% of these required critical care management; wheezing was identified in 29 patients (39.7%), and 11 patients (15.1%) required long-term oxygen therapy. All patients had a chest X-ray, which showed air trapping in 67.1%, followed by consolidation (65.8%) as main findings. HRCT was available in 68 patients with consolidation as the main finding (33.8%) and bronchiectasis only in 7 patients (10.3%).
Conclusions
In these pediatric patients with PAD, pneumonia and wheezing are the major respiratory comorbidities. Within the radiological findings, consolidation was the most frequent and the bronchiectasis rate was similar to local previous reports.