Poster Display
Therapy
IMPACT OF ROTAVIRUS VACCINE ON TRANSPLANT OUTCOME IN INFANTS WITH SCID
Lecture Time
10:36 - 10:37
Presenter
- Su Han Lum, United Kingdom
Room
Poster Area
Date
20.09.2019, Friday
Session Time
10:00 - 17:00
Presentation Topic
Therapy
Abstract
Background and Aims
Rotavirus vaccines have been reported to cause enteropathy in infants who received vaccine prior to a diagnosis of SCID.
Methods
We studied the impact of rotavirus vaccine on transplant outcome in 24 infants with SCID transplanted at the Great North Children’s Hospital between 2013 and 2018.
Results
7 patients diagnosed at birth did not receive rotavirus vaccine. Rotavirus vaccine was associated with increased incidence of acute GvHD (p=0.03), increased need of PN (p=0.01) and increased need for ICU (p=0.03).
| No rotavirus vaccine | rotavirus vaccine | p-value | |
| Number | 12 | 12 | |
| Median age at diagnosis (range), months | 0.6(birth–13.6) | 4.6(2.8-7.1) | 0.005 |
| Median age at transplant (range), months | 2.4(1.0 – 15.4) | 7.4(3.4-9.4) | 0.005 |
| Median interval transplant to diagnosis (range), months | 1.9(0.24– 2.6) | 1.6(0.6-4.1) | 0.64 |
| BCG vaccination, n | 4 | 1 | 0.16 |
| PCP, n | 0 | 6 | 0.01 |
| Growth failure, n | 3 | 6 | 0.4 |
| Conditioned transplant, n (%) | 11(92) | 10(83) | 0.5 |
| MFD | 5(42) | 3(25) | |
| MUD | 4(22) | 4(33) | |
| Haploidentical | 3(25) | 4(42) | |
| Stem cell | 0.80 | ||
| Marrow | 5 | 3 | |
| PBSC | 1 | 1 | |
| TCR ab/CD19 PBSC | 2 | 3 | |
| CB | 3 | 5 | |
| Median TNC (range), 108/kg | 11.5(0.93-40.0) | 9.65(0.21-53.0) | 0.45 |
| Median CD34 (range), 106/kg | 11.3(1.9-96.0) | 0.4(0.5-26.6) | 0.98 |
| aGvHD, n | 0 | 4 | 0.03 |
| PN, n | 3 | 9 | 0.01 |
| Median days of PN (range) | 36(26-125) | 87(21-196) | 0.31 |
| PICU admission, n | 1 | 6 | 0.03 |
| Median days of PICU stay (range) | 0(0-39) | 16(0-25) | 0.05 |
| Median days of total inpatient stay (range) | 83.5(0-168) | 129.5(26-341) | 0.13 |
Conclusions
Rotavirus vaccine is associated with significant transplant morbidity for infants with SCID