Poster Author of 1 e-Poster
SE-062 - Magnetic Resonance Imaging Features of Primary Biliary Cholangitis
Author of 1 Presentation
SE-062 - Magnetic Resonance Imaging Features of Primary Biliary Cholangitis
Abstract
Purpose
To evaluate MRI features of the liver in PBC patients in a large cohort and also correlate with histological findings
Material and methods
283 patients with PBC underwent an MRI. MRI studies were reviewed by two abdominal radiologists in consensus for liver morphology, signal intensity, post-contrast enhancement and signs of decompensation. Liver and spleen volumes and normalized liver apparent diffusion coefficient (nlADC) were also calculated. MRI features were correlated with fibrosis stage among a subset of 62 patients who had a liver biopsy within 6 months (n=72).
Results
The study population comprised of 253 (89 %) females and a mean ± SD age of 59.4 ± 11.8 years. Lymphadenopathy (78.1 %), periportal hyperintensity (36.7 %), and periportal halo sign (27.6 %) were most common . A positive correlation was found between fibrosis stage and spleen size (r = 0.457, p< 0.001), spleen volume (r = 0.557, p < 0.001) and portal vein diameter (r = 0.287, p = 0.013) and a negative correlation with nlADC (r = -0.332, p = 0.011). Fibrosis stage also correlated with presence of surface nodularity (p < 0.001), periportal halo sign (p = 0.04), collaterals (p = 0.033) and splenomegaly (p =0.002). No significant differences in nlADC values were found in different fibrosis stages. The periportal halo sign was present in only patients with significant fibrosis. None of the MRI features significantly correlated with inflammation grade.
Conclusion
Periportal halo sign correlates with significant fibrosis In PBC. Heterogeneous T2W intensity and post-contrast enhancement correlate with fibrosis stages and may predict advanced fibrosis
Author of 1 Presentation
SS 1.4 - Comparison of liver stiffness measurement with MR elastography and liver and spleen volumetry for the prediction of disease severity and hepatic decompensation in patients with primary sclerosing cholangitis (ID 382)
Abstract
Purpose
The aim of this study was to evaluate liver stiffness measures (LSM) with MR elastography (MRE) and volumetry measurements of liver and spleen and their correlation with disease severity and prediction of hepatic decompensation.
Material and methods
This retrospective study was approved by the institutional review board. MRI and MRE studies were reviewed and mean liver stiffness of the, total liver, right lobe, left lobe and caudate lobe, and spleen volumes were calculated. Qualitative evaluation of lobar atrophy or hypertrophy and the presence of macronodular regeneration (MNR) was recorded. Statistical analysis was performed to evaluate correlations between LSM, volumetry measurements and Mayo risk score. Univariate and multivariate analyses were performed to predict hepatic decompensation.
Results
A total of 266 patients with PSC were included in the study. Lobar stiffness measures were higher in the presence of relative lobe atrophy. Mean LSM was higher in the presence of MNR. Significant correlations were observed between mean LSM and volumetry measurements with a fair correlation between LSM and spleen volume (rs=0.526, p<0.0001). Among the measurements, the best correlation was observed between mean LSM and Mayo risk score (rs=0.646, p<0.0001). In the multivariate analyses, mean LSM and Mayo risk score were significantly associated with the liver decompensation (hazard ratio, 1.18; 95%CI, 1.02-1.36 and hazard ratio, 1.65; 95%CI, 1.08-2.53, respectively).
Conclusion
LSM with MRE performs significantly better than liver and spleen volumes for the prediction of both disease severity and hepatic decompensation.