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SE-010 - CT texture analysis of gastric cancer without synchronous peritoneal carcinomatosis (NPCGC) versus gastric cancer with synchronous peritoneal carcinomatosis (PCGC).
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SE-010 - CT texture analysis of gastric cancer without synchronous peritoneal carcinomatosis (NPCGC) versus gastric cancer with synchronous peritoneal carcinomatosis (PCGC).
Abstract
Purpose
To compare CT texture analysis and CT features of gastric cancer with synchronous peritoneal carcinomatosis (PCGC) versus features of gastric cancer without synchronous peritoneal carcinomatosis (NPCGC) at the moment of diagnosis.
Material and methods
Contrast-enhanced CT images of 24 patients with gastric cancer without synchronous peritoneal carcinomatosis and 24 patients with synchronous peritoneal carcinomatosis were analysed with 3D CT texture analysis (performed by TexRAD) in portal phase. The Region of Interest (ROI) was manually drawn along the margin of the lesion for each image. The following parameters have been evaluated: "Mean Attenuation", "Standard Deviation", "Skewness", "Kurtosis", "Entropy" and "Mean of Positive Pixel". The CT exams were performed before the beginning of any medical treatment or surgery. Data were analysed with Mann-Whitney test. Radiomics results have been correlated with size, histologic specimen and oncologic grading.
Results
Concerning histologic type, all patients have been demonstrated to have a gastric adenocarcinoma. At least oncologic grade 3 was found in 31 out of 48 patients. Among CT texture analysis, in a comprehensive comparison between PCGC and NPCGC, the parameter "Mean" was significantly higher in PCGC (p value<0.05) for all the Spatial Scaling Factors (SSF). The parameter “Skewness” was significantly higher in PCGC (p value<0.05), moreover for SSF3. The parameter “Entropy” was significantly higher in PCGC (p value<0.05) for SSF0, SSF5 e SSF6.
Conclusion
The results of our study demonstrate significant differences between CT texture parameters of gastric tumoral lesions in PCGCs and NPCGCs, and highlight the diversity of the two groups, for at least three parameters.