Poster Author of 1 e-Poster
SE-018 - Biliary involvement in liver metastases: long term results of endobiliary biopsy from a single center experience
Author of 1 Presentation
SE-018 - Biliary involvement in liver metastases: long term results of endobiliary biopsy from a single center experience
Abstract
Purpose
To investigate long term results of endobiliary biopsy performed with a transluminal forceps set in metastatic biliary involvement.
Material and methods
Between September 2014 and June 2019, 25 patients (18 male (72%), mean age 65± 15 years) underwent 26 biliary forceps biopsy procedures with a dedicated set (Cook Medical, USA). All patients presented with obstructive jaundice, suspected malignant, and pre-procedural MR-cholangiopancreatography was obtained. The procedure was performed during percutaneous internal-external biliary drainage positioning, under fluoroscopic guidance. The study’s primary endpoints included technical success and complications rates. The study’s secondary endpoints were sensitivity, specificity and diagnostic accuracy for the characterization of malignancy.
Results
Technical success rate was 96% (25 cases) with histological diagnosis of phlogistic stenosis in 5 cases, 6 case of pancreatic adenocarcinoma, 8 colon rectal liver metastases, 3 hepatocellular carcinoma and 3 cases of normal biliary mucosa. In 1 case the sample was considered insufficient by the pathologist (1 pancreatic adenocarcinoma) and the procedure was successfully repeated. The 6 to 48 months follow-up showed 5 false negative cases, in particular 2 case of non colon rectal liver metastases (breast and gastric cancer) and 3 metastatic hilar lymph nodes. The statistical analysis revealed a sensitivity of 77%, specificity of 100% and overall accuracy of 80%. The complications rate was 11,5% (3 cases with transient haemobilia).
Conclusion
Transluminal biliary biopsy performed with forceps set is a safe and effective minimally invasive procedure for histological characterization in patients presenting with obstructive jaundice due to non-primary biliary tumor.