Author of 1 Presentation
SS 6.2 - MR enterography before treatment may predict response to tumour necrosis factor-alpha inhibitors in Crohn's disease
Abstract
Purpose
Identifying predictors of therapeutic response is the cornerstone of personalized medicine. We aimed to identify predictors of long-term healing of severe inflammatory lesions detected at MR enterography (MRE) in patients with Crohn’s disease treated with tumor necrosis factor-alpha (TNF-α) inhibitors.
Material and methods
Prospective longitudinal single-center study including patients with clinically active Crohn’s disease requiring treatment with TNF-α inhibitors with at least one intestinal segment with a severe inflammatory lesion detected by MRE (segmental MaRIA ≥ 11). MRE data were obtained at baseline, week-14, and week-46. The primary endpoint was the healing of severe inflammatory lesions (MaRIA < 11) in each segment. The secondary endpoint was healing of all severe inflammatory lesions in all intestinal segments.
Results
We included 58 patients with 86 intestinal segments with severe inflammatory lesions. At week-46, healing of severe lesions was found in 51 (59.3%) segments, and complete healing of inflammatory all lesions in all segments was found in 28 (48.6%) patients. Multivariate analysis found predictors of healing colonic location (as opposed to ileal) (OR 4.5 [1.2-17.2]; p=0.024) and lack of creeping fat at MRE (OR 4.3 [1.7–17.6]; p=0.04). Healing on MRE at week-14 is an independent predictor of sustained healing at week-46 (OR 11 [2.1-57.1]; p=0.004).
Conclusion
In patients with Crohn’s disease, the absence of creeping fat detected at pretreatment MRE and location of severe inflammatory lesions are clinically relevant predictors of long-term healing of severe inflammation after treatment with TNF-α inhibitors.
Slides
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SS6.2 Rimola no voice ESGAR Fri, 08.05.2020 20:29
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SS6.2 Rimola VOICE ESGAR Fri, 08.05.2020 20:30
Video-on-demand
Author of 1 Presentation
SS 6.2 - MR enterography before treatment may predict response to tumour necrosis factor-alpha inhibitors in Crohn's disease (ID 401)
Abstract
Purpose
Identifying predictors of therapeutic response is the cornerstone of personalized medicine. We aimed to identify predictors of long-term healing of severe inflammatory lesions detected at MR enterography (MRE) in patients with Crohn’s disease treated with tumor necrosis factor-alpha (TNF-α) inhibitors.
Material and methods
Prospective longitudinal single-center study including patients with clinically active Crohn’s disease requiring treatment with TNF-α inhibitors with at least one intestinal segment with a severe inflammatory lesion detected by MRE (segmental MaRIA ≥ 11). MRE data were obtained at baseline, week-14, and week-46. The primary endpoint was the healing of severe inflammatory lesions (MaRIA < 11) in each segment. The secondary endpoint was healing of all severe inflammatory lesions in all intestinal segments.
Results
We included 58 patients with 86 intestinal segments with severe inflammatory lesions. At week-46, healing of severe lesions was found in 51 (59.3%) segments, and complete healing of inflammatory all lesions in all segments was found in 28 (48.6%) patients. Multivariate analysis found predictors of healing colonic location (as opposed to ileal) (OR 4.5 [1.2-17.2]; p=0.024) and lack of creeping fat at MRE (OR 4.3 [1.7–17.6]; p=0.04). Healing on MRE at week-14 is an independent predictor of sustained healing at week-46 (OR 11 [2.1-57.1]; p=0.004).
Conclusion
In patients with Crohn’s disease, the absence of creeping fat detected at pretreatment MRE and location of severe inflammatory lesions are clinically relevant predictors of long-term healing of severe inflammation after treatment with TNF-α inhibitors.
Slides
-
SS6.2 Rimola no voice ESGAR Fri, 08.05.2020 20:29
-
SS6.2 Rimola VOICE ESGAR Fri, 08.05.2020 20:30