Poster Author of 1 e-Poster
SE-073 - Observational sub-study of elevated liver iron inferred from R2* values obtained by MR imaging at two study centers as part of the Strong Heart Study (SHS) in American Indians
Author of 1 Presentation
SE-073 - Observational sub-study of elevated liver iron inferred from R2* values obtained by MR imaging at two study centers as part of the Strong Heart Study (SHS) in American Indians
Abstract
Purpose
To determine whether elevated liver iron in two populations of American Indians exceeds what is expected from genetics.
Material and methods
Liver MRIs were evaluated for 300 consecutively-enrolled American Indians from two study centers in different parts of the United States as part of the ongoing SHS, stratified for obesity, diabetes, and alcohol consumption (87M, 208F, 5 unknown; mean age 50.7 yrs). For each participant, C282Y and H63D mutations and alcohol consumption history were collected, and PDFF and R2* values were derived from MRIs. Percentages of participants with 3T-equivalent R2* values in the 80-100 s-1 range and >100 s-1 were tabulated and compared to expected percentages based on (C282Y/H63D) genetics.
Results
3.3% (10/300) of participants had R2* > 100 s-1 (range 101 to 818 s-1; 3 from Site 1, 7 from Site 2), and 10.0% (30/300) of participants had R2* in the 80-100 s-1 range (29 from Site 1, 1 from Site 2). None of the first 160 participants were homozygous for either mutation. 64.3% (193/300) of participants had PDFF > 6%, a commonly accepted cutoff for fatty liver. 35.9% (99/276) of responding participants reported heavy episodic drinking.
Conclusion
The observed elevated prevalence of inferred liver iron in American Indians at two study centers appears not to be explainable by genetics alone and, the higher prevalence at Site 1 is unexplained. Given the high observed prevalences of fatty liver and heavy episodic drinking, these findings may be related to coincident nonalcoholic and/or alcoholic fatty liver disease, and to population differences between the two sites.