Author of 1 Presentation
SS 14.6 - Correlation between medical outcome and US, shear-wave elastography and MRI findings in native liver survivor patients with biliary atresia after Kasai portoenterostomy
Abstract
Purpose
Biliary atresia (BA) is an obliterative cholangiopathy and Kasai portoenterostomy (KP) represents its first-line treatment. Clinical and laboratory parameters together with abdominal US are usually performed during the follow-up. Shear-wave elastography (SWE) is able to evaluate liver parenchyma stiffness and MRI has also been proposed to study these patients. The aim of our study is to correlate US, SWE and MRI findings with medical outcomes in native liver survivor patients with BA after KP.
Material and methods
Twenty-four patients were retrospectively enrolled and divided into two groups based on “ideal” (n=15) or “non-ideal” (n=9) medical outcome defined according to clinical and laboratory parameters. US, SWE and MRI exams were analyzed qualitatively and quantitatively for imaging signs suggestive of chronic liver disease (CLD).
Results
Significant differences were found in terms of liver surface (p= 0.007) and morphology (p= 0.013), portal vein diameter (p= 0.012) and spleen size (p= 0.002) by US, liver signal intensity (p= 0.013), portal vein diameter (p= 0.010), presence of portosystemic collaterals (p= 0.042) and spleen size (p= 0.001) by MRI. The evaluation of portal vein diameter (moderate, κ= 0.44), portosystemic collaterals (good, κ= 0.78) and spleen size (very good, κ= 0.92) showed the best agreement between US and MRI. A significant (p= 0.01) difference in liver parenchyma stiffness by SWE was also found between the two groups (cut-off=9.6 kPa, sensitivity=55.6%, specificity=100%, area under the ROC curve=0.82).
Conclusion
US, SWE and MRI findings correlate with the medical outcome in native liver survivor patients with BA after KP.
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Author of 1 Presentation
SS 14.6 - Correlation between medical outcome and US, shear-wave elastography and MRI findings in native liver survivor patients with biliary atresia after Kasai portoenterostomy (ID 862)
Abstract
Purpose
Biliary atresia (BA) is an obliterative cholangiopathy and Kasai portoenterostomy (KP) represents its first-line treatment. Clinical and laboratory parameters together with abdominal US are usually performed during the follow-up. Shear-wave elastography (SWE) is able to evaluate liver parenchyma stiffness and MRI has also been proposed to study these patients. The aim of our study is to correlate US, SWE and MRI findings with medical outcomes in native liver survivor patients with BA after KP.
Material and methods
Twenty-four patients were retrospectively enrolled and divided into two groups based on “ideal” (n=15) or “non-ideal” (n=9) medical outcome defined according to clinical and laboratory parameters. US, SWE and MRI exams were analyzed qualitatively and quantitatively for imaging signs suggestive of chronic liver disease (CLD).
Results
Significant differences were found in terms of liver surface (p= 0.007) and morphology (p= 0.013), portal vein diameter (p= 0.012) and spleen size (p= 0.002) by US, liver signal intensity (p= 0.013), portal vein diameter (p= 0.010), presence of portosystemic collaterals (p= 0.042) and spleen size (p= 0.001) by MRI. The evaluation of portal vein diameter (moderate, κ= 0.44), portosystemic collaterals (good, κ= 0.78) and spleen size (very good, κ= 0.92) showed the best agreement between US and MRI. A significant (p= 0.01) difference in liver parenchyma stiffness by SWE was also found between the two groups (cut-off=9.6 kPa, sensitivity=55.6%, specificity=100%, area under the ROC curve=0.82).
Conclusion
US, SWE and MRI findings correlate with the medical outcome in native liver survivor patients with BA after KP.