Poster Author of 2 e-Posters
SE-048 - Evaluation of Diagnostic Value of CT-Enterography and 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography (PET/CT) for The Detection of The Primary Lesion in Patients with Small Intestinal Neuroendocrine Tumors
SE-049 - Choice of The Imaging Method for The Detection of The Primary Lesion in Neuroendocrine Tumors of The Small Bowel
Author of 2 Presentations
SE-048 - Evaluation of Diagnostic Value of CT-Enterography and 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography (PET/CT) for The Detection of The Primary Lesion in Patients with Small Intestinal Neuroendocrine Tumors
Abstract
Purpose
To evaluate the diagnostic value of preoperative CT-Enterography and 68Ga-DOTATATE PET/CT to determine primary lesion and multifocality in patients with small intestinal neuroendocrine tumors (siNETs).
Material and methods
Between January 2017 and June 2019, eighteen patients with histopathologically proven siNETs undergoing preoperative CT-Enterography and 68Ga-DOTATATE PET/CT were reviewed. Pathology results were accepted as the gold standard and CT-enterography and 68Ga-DOTATATE PET/CT reports were evaluated retrospectively. The sensitivity of CT-Enterography and 68Ga-DOTATATE PET/CT was calculated for the diagnosis of the primary lesion and multifocality in siNETs.
Results
The sensitivity of CT-Enterography in the detection of the patient with siNETs, and the number of primary lesions were (18/18) 100% and (29/42) 69%, respectively. The sensitivity of and 68Ga-DOTATATE PET/CT in the detection of the patient with siNETs, and the number of primary lesions were (17/18) 94.4% and (25/42) 59.5%, respectively.
Conclusion
According to our preliminary results, the sensitivity of CT-Enterography in detecting patients with siNETs and the number of primary lesions is higher than68Ga-DOTATATE PET/CT. CT-Enterography is considered an excellent imaging modality for the diagnosis of siNETs before treatment planning.
SE-049 - Choice of The Imaging Method for The Detection of The Primary Lesion in Neuroendocrine Tumors of The Small Bowel
Abstract
Purpose
The purpose of this study was to conduct a systematic review of the literature on primary tumor detection in small intestinal neuroendocrine tumors (siNETs) and to compare the sensitivity of different imaging methods.
Material and methods
Systematic overview methods, an electronic search was conducted in the English-language literature through PubMed/MEDLINE in order to identify all original research studies for the detection of the primary lesion in siNETs. A literature search was conducted using a combination of the keywords including neuroendocrine, bowel, intestine, radiology, CT, MR, PET. Of the 371 studies yielded by search, 14 were included.
Results
The sensitivity of at least one imaging modality is presented in each of the 14 articles included in the study. The sensitivity of different imaging modalities in the detection of primary lesion siNETs was found as follows: Computed Tomography (CT) or Magnetic Resonsance (MR) (n:101, 25-48%), CT-enterography (n:18, 89.9%), CT-enteroclysis (n:40, 80-100%), MR-enterography (n:19, 94.7%), MR enteroclysis (n:15, 93.3%,) capsule endoscopy (n:54, 27.3-60%), Somatostatin receptor scintigraphy (n:103, 23.5-85%), and 68Ga-DOTATATE PET/CT (n:104, 89.3-100%), 18F-FDOPA PET/CT (n:17, 100%) and 18F-FDG PET/CT (n:10, 60%).
Conclusion
Although neuroendocrine tumors are the most common small bowel after the pancreas, there are limited comparative studies to provide recommendations regarding optimal diagnostic methods to detect the siNETs. Among the currently used imaging tools, both CT and MR-enterography providing high anatomical detail and the Ga-68 DOTATOC PET/CT providing functional information appear to be most suitable. Further research efforts are needed to establish a roadmap for imaging of the primary lesion in siNETs.