Author of 1 Presentation
SS 3.10 - Prediction of early recurrence after surgery in patients with pancreatic neuroendocrine tumour using preoperative MRI
Abstract
Purpose
To investigate important MRI features for predicting early recurrence in patients with pancreatic neuroendocrine tumor (PNET) after surgery.
Material and methods
A total of 100 patients (mean age 55.8 years; M:F, 49:51) with PNET who underwent MRI and first-line surgery from 2000 to 2018 were included. Two radiologists independently assessed MRI findings including size, location, margin, T1- and T2-signal intensity, enhancement patterns, CBD and pancreatic duct dilatation, vascular invasion, LN enlargement, DWI, ADC value, retrospectively. Survival and clinicopathologic data including underlying disease, tumor grade, TNM stage, resection margin and postoperative complications were collected. Image findings associated with disease-free survival and overall survival were assessed with Kaplan-Meier survival analysis and multivariate Cox proportional hazard regression analysis.
Results
The mean disease-free survival and overall survival of the patients were 115.3 [96.8-133.9] and 130.0 [119.4-140.7] months, respectively. Among the variables, arterial iso- to hypo-enhancement, portal iso- to hypo-enhancement, ductal dilatation, arterial invasion, venous invasion, lymph node enlargement, larger tumor size and higher histologic grade showed significant early recurrence (p< 0.05) and poor overall survival (p< 0.05) in univariate analysis. In multivariate analysis, portal iso- to hypo-enhancement (HR 23.12 [2.72-196.4] (p=0.004)), ductal dilatation (HR 4.76 [1.13-19.95] (p=0.033)), arterial invasion (HR 72.13 [4.63-1123.31] (p=0.002)), venous invasion (HR 6.35 [1.80-22.43] (p=0.004)) and tumor size (HR 1.03 [1.00-1.07] (p=0.046)) showed significant effect on early recurrence. However, there was no significant variable for overall survival.
Conclusion
MRI features including size, enhancement pattern, vascular invasion and ductal dilatation are useful in predicting early recurrence after surgery in patients with PNET.
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Author of 1 Presentation
SS 3.10 - Prediction of early recurrence after surgery in patients with pancreatic neuroendocrine tumour using preoperative MRI (ID 432)
Abstract
Purpose
To investigate important MRI features for predicting early recurrence in patients with pancreatic neuroendocrine tumor (PNET) after surgery.
Material and methods
A total of 100 patients (mean age 55.8 years; M:F, 49:51) with PNET who underwent MRI and first-line surgery from 2000 to 2018 were included. Two radiologists independently assessed MRI findings including size, location, margin, T1- and T2-signal intensity, enhancement patterns, CBD and pancreatic duct dilatation, vascular invasion, LN enlargement, DWI, ADC value, retrospectively. Survival and clinicopathologic data including underlying disease, tumor grade, TNM stage, resection margin and postoperative complications were collected. Image findings associated with disease-free survival and overall survival were assessed with Kaplan-Meier survival analysis and multivariate Cox proportional hazard regression analysis.
Results
The mean disease-free survival and overall survival of the patients were 115.3 [96.8-133.9] and 130.0 [119.4-140.7] months, respectively. Among the variables, arterial iso- to hypo-enhancement, portal iso- to hypo-enhancement, ductal dilatation, arterial invasion, venous invasion, lymph node enlargement, larger tumor size and higher histologic grade showed significant early recurrence (p< 0.05) and poor overall survival (p< 0.05) in univariate analysis. In multivariate analysis, portal iso- to hypo-enhancement (HR 23.12 [2.72-196.4] (p=0.004)), ductal dilatation (HR 4.76 [1.13-19.95] (p=0.033)), arterial invasion (HR 72.13 [4.63-1123.31] (p=0.002)), venous invasion (HR 6.35 [1.80-22.43] (p=0.004)) and tumor size (HR 1.03 [1.00-1.07] (p=0.046)) showed significant effect on early recurrence. However, there was no significant variable for overall survival.
Conclusion
MRI features including size, enhancement pattern, vascular invasion and ductal dilatation are useful in predicting early recurrence after surgery in patients with PNET.