Objectives

The aim of this presentation is to provide an overview of ⁶⁸Ga- DOTATATE PET CT as useful diagnostic tool finding the primary tumor sites when this are unknown or uncertain on conventional workup.

Background

⁶⁸Ga-DOTATATE PET CT has demonstrated clear advantages in lesion detection of well-differentiated NET over conventional imaging. Accurate localization of tumor sites including primary tumor in patients with suspected NET is crucial for treatment planning, especially when surgery is being considered.

Imaging findings OR Procedure findings

A cohort of 25 patients (12 men and 13 women; median age, 50.7 years [range: 37-83]) with clinical history and/or biochemical suspicion of NET with negative or equivocal conventional imaging or biopsy proved NET metastases with unknown primary site. This selected population were identified from an ongoing Provincial ⁶⁸Ga-DOTATATE PET CT Registry (NCT03873870)

PET CT was performed between April 2019 to November 2019 at our Institution.

Identification of primary tumor was determined and classified according site (Gastrointestinal primary, Pancreas, or Other). Ilustrative cases in these different scenarios will be presented.

Conclusion

⁶⁸Ga-DOTATATE PET CT is a powerful tool for NET primary site identification in the aforementioned selected population in order to tailor treatment planning, specially when surgery is being considered.