S. MARIGNIER, France

CH LE VINATIER Centre de Ressources Autisme Rhône Alpes
I am a child neurologist, I work in 2 Hospitals in Bron, near Lyon, in France. In Center of Autism Ressources in Hospital Center Le Vinatier, I work in an early diagnosis team, and coordonate a research programm for early diagnosis with first line professionals. In Pediatric Hospital, Hôpital Femme Mère Enfant, I work in a child neuologists team , we receive patients with neurodevelopmental disorders in order to realise neurologic and genetics explorations.

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 Conference Calendar
Oral Communications (ID 1110) AS42. Research Methodology

O246 - Early screening of Autism Spectrum Disorder in general and pediatric practices, nurseries and early child care centers: KitCAT French study protocol using a two-stage procedure.

Session Name
Oral Communications (ID 1110)
Date
Sat, 10.04.2021
Session Time
07:00 - 21:00
Room
On Demand
Lecture Time
20:36 - 20:48
Presenter

ABSTRACT

Introduction

Early screening of children at-risk to develop Autism Spectrum Disorder (ASD) needs to be improved to propose early interventions. This detection should allow diagnosis of ASD before the age of 3. An early screening performed at the general practitioner of the family should facilitate accessibility to diagnosis and a better collaboration between professionals.

Objectives

Our primary objective is to estimate the positive predictive value of an early detection kit composed of 2 questionnaires (First screening: M-CHAT-R/F™ + CSBS DP™-ITC) and a confirmation of the detection with a phone call by a neuropsychologist. Patients with confirmed positive M-CHAT-R/F™ and/or CSBS DP™-ITC scores are referred to a level 2 team for pre-diagnosis and diagnosis assessment.

Methods

The KitCAT study is a cohort study of 1,700 children aged 16 to 24 months seen in routine care in general or pediatric practices, or in nurseries and child care centers.

Results

Seven hundred and five children have already been enrolled in the study. Twenty nine patients, ie 4.1%, (with a confirmed positive M-CHAT-R/F™ and/or CSBS DP™-ITC scores) were referred to a level 2 team where a pre-diagnosis assessment was conducted by using the following test: ADI-R, ADOS 2, BLR, WPPSI-IV and Vineland II. The diagnosis of ASD (using the same test than the pre-diagnosis) was confirmed for the first two patients aged of 3.

Conclusions

The preliminary results confirm that the use of 2 questionnaires may optimize the reliability of the screening. A thousand children are still needed for the final analysis and further results are expected.

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