A. Mukherjee, India

I am an early career psychiatrist currently working in India. I have completed my undergraduate medical education (MBBS) and post-graduate training in Psychiatry (MD Psychiatry) from Kasturba Medical College, Manipal, India. As part of my post-graduate thesis, I worked on the use of transcranial direct current stimulation in patients with Obsessive-Compulsive Disorder. This was an inspiring experience and greatly increased my interest in research, particularly in noninvasive brain stimulation techniques. During my post-graduation, I also received the highest score among MD Psychiatry candidates in the University Examination conducted in June 2020. I have also presented posters and a paper at state and national conferences and had the privilege of being awarded a Grant for the 29th European Congress of Psychiatry. I have experience working in both a general hospital psychiatric unit and psychiatric hospital settings. I am looking to further enhance my clinical skills and would like to venture into medical systems outside India to broaden my understanding of Psychiatry. My areas of interest include Adult Psychiatry, Women’s Mental Health, and Noninvasive Brain Stimulation, and I hope to pursue a career in the same.

Presenter of 1 Presentation

 Conference Calendar
Oral Communications (ID 1110) AS38. Psychosurgery & Stimulation Methods (ECT, TMS, VNS, DBS)

O234 - Effect of add-on cathodal transcranial direct current stimulation (c-tDCS) over pre-supplementary motor area (pre-SMA) in patients with obsessive compulsive disorder: A randomized sham controlled study

Session Name
Oral Communications (ID 1110)
Date
Sat, 10.04.2021
Session Time
07:00 - 21:00
Room
On Demand
Lecture Time
19:24 - 19:36
Presenter

ABSTRACT

Introduction

Patients with OCD often show unsatisfactory response to first-line treatment, giving rise to a need for novel therapeutic approaches. Recent studies using tDCS for OCD treatment have shown promise.

Objectives

To assess efficacy and safety of add-on c-tDCS over pre-SMA compared to sham stimulation in patients with OCD.

Methods

In this double-blinded study, fourteen patients with OCD were randomized to receive 10 sessions of either active (Cathode over pre-SMA, anode over right deltoid, 2mA, 20 minutes per session, 2 sessions per day, 2 hours apart) or sham tDCS. YBOCS, HAM-D, HAM-A, CGI, Wisconsin Card Sorting Test (WCST), and Stroop Test were administered at baseline, post-tDCS, and 1 month post-tDCS.

Results

Group×time interaction effect for YBOCS scores with Repeated Measures ANOVA was not statistically significant, however, reduction in scores in active group was higher, with large effect size (YBOCS scores: Obsessions-ηp2=.344, Compulsions-ηp2= .384, Total-ηp2=.392) (Fig.1 & 2). At 1 month, 42.9% patients in active group and none in sham group showed response.

CGI-S score (p=0.016, ηp2=.531) (Fig. 3) and four parameters of WCST (Perseverative responses:p=0.038, ηp2=.448;Percent perseverative responses:p=0.026, ηp2=.485;Percent perseverative errors:p=0.038, ηp2=.447;Trials to complete first category:p=0.011, ηp2=.563) significantly reduced in active group.

No significant difference in change in depressive and anxiety symptoms between groups, or change in Stroop Test performance was noted. Adverse effects included transient headache and tingling sensation.

fig. 1_ybocs obsessions.png

fig. 2_ybocs compulsions.png

fig. 3_cgi-s score.png

Conclusions

Cathodal tDCS over pre-SMA may be effective in reduction of obsessions, compulsions, illness severity, and enhancing cognitive flexibility in patients with OCD, with no major adverse effects. Larger studies are required to confirm these findings.

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