Concepts like person-centred or personalized care on the one hand and the newer term precision medicine have something in common, do partly overlap, but still elaborate different approaches to the patient. In some sense, they are borrowing from the bio-psycho-social model (Engel, 1980) in that they favor a multi-perspective approach to the ill person. But whereas the personalized approach has a more ‘holistic’ approach of the whole ‘person’ in mind, taking the ill person as an integrate unity of body, mind and brain with related needs, precision psychiatry as the newest concept aims at ‘tailoring of medical treatment to the individual characteristics of each patient … (by) classifying individuals into subpopulations that differ in their susceptibility to a particular disease or in their response to a specific treatment’ (NRC, 2011). However, although the genetic, neurobiological and technical state of the art is growing rapidly, their clinical applicability is still in its early adolescence (Perna et al., 2017). Persons with schizophrenia are the ones who profit most from a person-centred approach in early recognition, treatment, rehabilitation and care (Gaebel & Zielasek, 2016; Schizophrenia Guideline, DGPPN 2019). The broad spectrum of available effective interventions needs to be applied across an increasingly interconnected, integrated network of settings, in which the hospital is one component of a complex system of care. Hospital-based care like other components needs to follow the guidelines of person-centred care. The presentation will focus on the current state and future perspectives of hospital-based personalized treatment and care of schizophrenia.