Camilla D. Johannesen (Denmark)
Herlev and Gentofte Hospital
Department of Clinical Biochemistry
Camilla Ditlev Lindhardt Johannesen is an MD and PhD student at the Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev Gentofte, Denmark. She has a Bachelor of Engineering and furthermore graduated from University of Copenhagen 2018 as a medical doctor. Camilla lives in Copenhagen with husband and daughter. Her research area is within epidemiological studies on lipids, lipoproteins and apolipoproteins related to atherosclerotic cardiovascular diseases and death. During the first year of her PhD studies, she published two articles in high-impact journals (British Medical Journal and JACC) and a third article is currently under resubmission. Recently she was awarded a prize for Paper of the Year 2022 at the Scandinavian Atherosclerosis Conference.

Presenter of 1 Presentation

 Conference Calendar

IMPORTANCE OF APOB AND NON-HDL CHOLESTEROL FOR ISCHEMIC STROKE IS DOUBLE THAT OF LDL CHOLESTEROL

Session Name
0410 - Apo B containing lipoproteins (ID 8)
Session Type
Workshop - Lipids, lipoproteins
Date
Tue, 24.05.2022
Session Time
11:00 - 12:30
Room
Anitschkow - Silver Plenary hall
Presenter
Lecture Time
12:10 - 12:20

Abstract

Background and Aims

Conflicting results have been reported on the association between lipids and risk of ischemic stroke. We examined the burden of ischemic stroke attributable to apolipoprotein B (apoB), non-high-density lipoprotein (non-HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol.

Methods

We included 104 618 individuals from an ongoing cohort study, the Copenhagen General Population Study. The associations of quintiles of apoB, non-HDL cholesterol, and LDL cholesterol with risk of ischemic stroke were estimated by Cox proportional hazards regressions with 95% confidence intervals. With 1st quintile as reference, the proportion of ischemic stroke attributable to the 2nd, 3rd, 4th, and 5th quintiles of apoB, non-HDL cholesterol, and LDL cholesterol were estimated by the population attributable fraction (PAF).

Results

Quintiles of apoB and non-HDL cholesterol were associated with a stepwise increased risk of ischemic stroke, whereas only the upper two quintiles of LDL cholesterol were associated with increased risk of ischemic stroke. A similar pattern was seen for PAF values. Compared to the 1st quintile, the combined proportion of ischemic stroke attributable to individuals in the 2nd to 5th quintiles of apoB (levels > 82 mg/dL), non-HDL cholesterol (levels > 3.0 mmol/L, > 117 mg/dL), and LDL cholesterol (levels > 2.4 mmol/L, > 94 mg/dL) were 17.0%, 16.0%, and 8.4%, respectively.

Conclusions

The proportion of ischemic stroke attributable to elevated apoB and non-HDL cholesterol was double that attributable to elevated LDL cholesterol, indicating that the risk of ischemic stroke is better reflected by elevated apoB and non-HDL cholesterol than elevated LDL cholesterol.

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