Dr. Cuchel is a Research Associate Professor at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia. She is a translational scientist with a longstanding research interest in rare disorders of lipoprotein metabolism and the development of novel therapeutic strategies. Her research has had a significant impact on the development and regulatory approval of novel treatments for homozygous familial hypercholesterolemia as well as advancing our understanding of the role of genes affecting lipid and lipoprotein metabolism in human pathophysiology. In addition to the development of novel therapeutic approaches and the investigation of their mechanism of action, she has also investigated the association of cholesterol efflux capacity with atherosclerosis and led the development of a method to assess reverse cholesterol transport in humans that has been extensively validated in animal models.