Benjamin N. Wadström (Denmark)
Herlev og Gentofte Hospital Klinisk Biokemisk AfdelingAuthor Of 1 Presentation
O017 - Elevated remnant cholesterol and 3-fold increased risk of peripheral artery disease: two population-based cohorts (ID 1016)
Abstract
Background and Aims
Remnant cholesterol is observationally and causally associated with ischemic heart disease and ischemic stroke. Whether this is also true for Peripheral Artery Disease (PAD) is not known. We tested the hypothesis that elevated remnant cholesterol is associated with increased risk of PAD.
Methods
A total of 107,169 individuals from the Copenhagen General Population Study examined in 2003–2015 were included in a prospective, observational association study. During 15 years of follow-up, 1,587 individuals were diagnosed with PAD. Hazard ratios were estimated using Cox regression models. Results were independently confirmed in 13,972 individuals from the Copenhagen City Heart Study examined in 1976-78, with 1,033 cases of PAD diagnosed during 43 years of follow-up.
Results
Higher levels of remnant cholesterol were associated with a stepwise increase in the risk of PAD up to a multivariable adjusted hazard ratio of 3.1 (95% confidence interval: 2.2-4.2) for individuals with remnant cholesterol concentrations ≥1.5 mmol/l compared to individuals with remnant cholesterol <0.5 mmol/l. Corresponding results for myocardial infarction and ischemic stroke were 2.6 (2.0-3.4) and 1.6 (1.3-2.0). Cumulative incidence of PAD at age 80 ranged from 2.9% in individuals with remnant cholesterol <0.5 mmol/l to 8.9% in individuals with remnant cholesterol ≥1.5 mmol/l (Figure). Results in the Copenhagen City Heart Study were similar.
Conclusions
Elevated remnant cholesterol is associated with a 3-fold increased risk of PAD, higher than for myocardial infarction or ischemic stroke. Clinical trials should evaluate the effect of remnant cholesterol lowering therapy in the context of PAD.
Presenter of 1 Presentation
O017 - Elevated remnant cholesterol and 3-fold increased risk of peripheral artery disease: two population-based cohorts (ID 1016)
Abstract
Background and Aims
Remnant cholesterol is observationally and causally associated with ischemic heart disease and ischemic stroke. Whether this is also true for Peripheral Artery Disease (PAD) is not known. We tested the hypothesis that elevated remnant cholesterol is associated with increased risk of PAD.
Methods
A total of 107,169 individuals from the Copenhagen General Population Study examined in 2003–2015 were included in a prospective, observational association study. During 15 years of follow-up, 1,587 individuals were diagnosed with PAD. Hazard ratios were estimated using Cox regression models. Results were independently confirmed in 13,972 individuals from the Copenhagen City Heart Study examined in 1976-78, with 1,033 cases of PAD diagnosed during 43 years of follow-up.
Results
Higher levels of remnant cholesterol were associated with a stepwise increase in the risk of PAD up to a multivariable adjusted hazard ratio of 3.1 (95% confidence interval: 2.2-4.2) for individuals with remnant cholesterol concentrations ≥1.5 mmol/l compared to individuals with remnant cholesterol <0.5 mmol/l. Corresponding results for myocardial infarction and ischemic stroke were 2.6 (2.0-3.4) and 1.6 (1.3-2.0). Cumulative incidence of PAD at age 80 ranged from 2.9% in individuals with remnant cholesterol <0.5 mmol/l to 8.9% in individuals with remnant cholesterol ≥1.5 mmol/l (Figure). Results in the Copenhagen City Heart Study were similar.
Conclusions
Elevated remnant cholesterol is associated with a 3-fold increased risk of PAD, higher than for myocardial infarction or ischemic stroke. Clinical trials should evaluate the effect of remnant cholesterol lowering therapy in the context of PAD.