Professor Byrne trained as a clinical scientist in the UK and the US, at Cardiff, Cambridge and Stanford Universities and undertook a PhD studying liver lipid metabolism at Cambridge University. After a post-doctoral fellowship at Stanford University and then an MRC fellowship at Cambridge University, Prof Byrne was appointed in 1999 to the Chair of Endocrinology & Metabolism at the University of Southampton and was inaugural Director of the Wellcome Trust Clinical Research Facility at Southampton. Prof Byrne is a Metabolic Physician and is currently Principal Investigator within the NIHR Southampton Biomedical Research Centre focussing on research related to NAFLD. Prof Byrne has published over 370 publications related to metabolic syndrome and NAFLD and was a recipient of the Dorothy Hodgkin prize for research excellence related to diabetes. Prof Byrne was the expert diabetologist advisor to the NICE NAFLD Guidelines.