Steve Humphries is a world-renowned expert in cardiovascular genetics, a field in which he has worked for over 30 years. He worked at University College London from 1991, where he was the British Heart Foundation Professor of Cardiovascular Genetics. He retired in September 2015 and is the UCL Emeritus BHF Professor of Cardiovascular Genetics. Professor Humphries has an h index of >100 and has published over 700 papers and more than 230 review articles and has supervised 39 PhD and 8 MD thesis students. He has directed a major research programme to develop and implement molecular strategies to study the causes and clinical and psychological consequences of Familial Hypercholesterolaemia (FH). He was the Lead Advisor to the UK NICE guidelines on FH published in 2008, and for the NICE 2017 update of these guidelines. https://www.nice.org.uk/guidance/cg71 He directed the 2010 UK audit of FH services and has set up an FH Pediatric Register under the auspices of the RCP and RCPCH. https://www.rcplondon.ac.uk/projects/outputs/fh-paediatric-register He has published on the health economics of cascade testing for FH, and is the Director of the international FH mutation database. He is actively involved with teaching, ethics, and public awareness aspects of the development of genetic testing for complex late-onset disorders.