204 - Abdominal obesity is associated with arterial stiffness and carotid IMT in middle-aged, elderly rural community adults. (ID 344)
Abstract
Background and Aims
The relation between adiposity and arterial stiffness remains controversial. We determined the relation between visceral adipose tissue and atherosclerosis in middle-aged and elderly adults.
Methods
A total of 3085 participants (1374 male, 1711female; 62.6 years) were studied. The automatic vascular screening device (form PWV/ABI;Omron) was used to measure blood pressure and to determine arterial stiffness by brachial to ankle pulse wave velocity (baPWV) and arterial obstruction by ankle brachial index (ABI). Carotid intima-media thickness (IMT) was measured as carotid atherosclerosis. Visceral fat was measured by bioelectrical impedance analysis.
Results
Visceral fat were 110 cm2 (40-50ys), 109(50-60ys), 110(60-70ys),116(70ys-) in male, and in female, it was <80cm2 at all age. In abdominal obesity (>100cm2), BP, HbA1c, LDL-C, hsCRP, baPWV and IMT significantly high than in abdominal lean(<100cm2). Logistic regression analysis adjusted for age and sex confirmed that abdominal obesity and the odds ratio (OR) of PWV, IMT and ABI were 1.438(p=0.010), 1.358 and 2.387(p=0.035), respectively. The risk of PWV and OR of simple obesity, with DM, with dyslipidemia were 1.31, 3.38 and 1.55. The risk of IMT and OR of obesity with DM, with dyslipidemia were 1.20, 2.79 and 2.75. The risk of ABI and OR of obesity with DM, with dyslipidemia were 2.22, 5.80 and 7.77.
Conclusions
These results suggest that abdominal obesity revealed hypertension, DM and dyslipidemia. Abdominal obesity is associated with large artery stiffness, carotid atherosclerosis and peripheral artery obstruction. These findings support the importance of adiposity measures as a risk factor for atherosclerosis in rural community adults
