206 - Pulse Wave Velocity with an Oscillometric Method in comparison with a Tonometric Method: a population-based study (ID 468)
Abstract
Background and Aims
Oscillometric pulse wave velocity (o-PWV) represents an attractive, non invasive and non operator-dependent method to estimate arterial stiffness in clinical practice. Tonometric carotid-femoral measurements (cf-PWV), is considered the gold-standard for non-invasive aortic stiffness assessment. Recent findings raised uncertainty about the clinical utility of o-PWV estimates. However, to date, no studies in the general population comparing the two methods have been performed.
Methods
A total of 1162 subjects in Switzerland were recruited from June 2017 to July 2018. Cf-PWV and o-PWV were assessed using SphygmoCor and Mobil-O-Graph systems, respectively.
Results
In all population, in-office o-PWV showed values significantly higher than cf-PWV (7.3vs.6.9m/sec,p≤0.001); the mean 24 hour and daytime o-PWV did not significantly differ. The Bland and Altman analysis showed a moderate agreement between 24h o-PWV and cf-PWV (mean difference -0.99, limits of agreement 4.23 to -6.22m/s). O-PWVs values underestimate arterial stiffness than tonometric cf-PWVs measurements under 50 years, overestimating PWVs over 50 years (all p-value≤0.001). Systolic blood pressure (SBP) and age weakly affect cf-PWV (r20.35) whilst explain the 98.4% of 24h o-PWV, indicating that <2% of o-PWV estimates were independent from them. In <30 year olds a strong relationship between o-PWV and SBP (r20.78) reducing as age increases (r20.17,≥70 years) was seen. Analysing the impact of age, an opposite trend was noticed (r20.08<30 years;r20.75,>70years).
Conclusions
Our findings suggest that o-PWV do not provide reliable arterial stiffness estimates in the general population; supplying different, mainly algorithm related information. Studies aimed at analysing further the relationship between cf- and o-PWV are advocated.
