Welcome to the 9th EAPS Congress Programme Scheduling

Abstract Body

Pharmacokinetic and pharmacodynamics of drugs adopted in pediatric population require knowledge and accuracy. If patients are in critical condition, organ insufficiency and drug interactions due to multiple treatments make the situation harder.

In PICU the use of drugs is complex and difficult especially in some areas and it may cause adverse effects if it is not accurate (inefficacy, organ failure development, or medical errors).

Altered pharmacokinetics have been reported in patients with sepsis or burns. Acute Kidney Insufficiency is a key factor to be considered in drug prescription and adjusting. Extracorporeal treatments (ECMO, CRRT) need to modify drug dosage considering the changed pharmacokinetics of many adopted molecules (analgesics and sedatives, antibiotics, antifungals, anticonvulsants, immunomodulators..)

Pharmacology is an essential part in PICU. Knowledge of pharmacology should be further developed and improved.