Up to 50% of pts with breast cancer and germline pathogenic/likely pathogenic
We conducted a retrospective cohort study using the US Electronic Health Record-derived de-identified Flatiron Health database. We selected pts ≥18 years with HR+ HER2-negative eBC, diagnosed from March 2007–October 2022 with a confirmed ODX RS. g
A total of 3672 pts with a confirmed ODX RS (category: low n=961; intermediate n=2172; high n=539) were included. Median age was 62 years (IQR 53, 69), 75.6% were white and 83.4% received treatment at community oncology clinics. Of 1163 pts (31.7%) tested, 37 (3.2%) had g Rates of g *Between 2007 and 2010 only 8 ODX RS tests were performed, and so data are not shown. ODX RS, Oncotype DX Recurrence Score.
Rate of g 2011–2014 2015–2018 2019–2022 Overall 13.7% 22.4% 32.4% ODX RS High 12.1% 26.3% 30.8% ODX RS Intermediate 14.5% 21.5% 32.9% ODX RS Low 12.4% 22.2% 32.1%
In this modern retrospective cohort, ODX RS appeared higher in g
Writing and editorial assistance was provided by Sara Shaw PhD CMPP of BOLDSCIENCE Inc., funded by AstraZeneca and MSD.
AstraZeneca.
This study was supported by AstraZeneca and Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, who are codeveloping olaparib (MSD).
F. Lynce: Financial Interests, Personal and Institutional, Advisory Board: AstraZeneca; Financial Interests, Personal and Institutional, Research Grant: AstraZeneca; Financial Interests, Personal, Advisory Board: Pfizer, Merck, Daiichi Sankyo; Financial Interests, Institutional, Research Grant: Eisai, CytomX, Incyte. R.A. Khan: Financial Interests, Personal, Full or part-time Employment: AstraZeneca. L. Berrocal-Almanza: Financial Interests, Personal, Full or part-time Employment: AstraZeneca; Financial Interests, Personal, Stocks/Shares: AstraZeneca. M. Miranda: Financial Interests, Personal, Full or part-time Employment: AstraZeneca; Financial Interests, Personal, Stocks/Shares: AstraZeneca. L. Luo: Financial Interests, Personal, Full or part-time Employment, I am a full time employee at AstraZeneca AstraZeneca; Financial Interests, Personal, Stocks/Shares, I have AstraZeneca stocks/shares: AstraZeneca. X. Xu: Financial Interests, Personal, Full or part-time Employment: AstraZeneca; Financial Interests, Personal, Stocks/Shares: AstraZeneca. All other authors have declared no conflicts of interest.