E. Gusbi (Tripoli, Libya)
Biotechnology And research CenterAuthor Of 1 Presentation
167P - Reproductive factors and hormonal contraceptives in relation with breast cancer histopathology.
Abstract
Background
The association between breast cancer (BC) and hormonal contraceptives (HC) has been thoroughly studied.However the effect of the type of HC on molecular subtypes of BC has not been clearly recognized especially in the Arabic region. This study examined the patterns of BC molecular subtypes according to the type of HC used and reproductive factors.
Methods
We conducted a study of invasive breast cancer among 500 women attending the breast cancer clinics in Tripoli, Libya from 2010 to 2020. We collected information on contraceptive use and reproductive factors.
Results
We found that 247 women diagnosed with BC in 10 years have taken the HC.The mean age of OC group was 43.72+/- 9.77 with 43.3% were 40 years old or younger. According to reproductive factors, age of menarche was less than 13 in 21.9%; age of 1st pregnancy being in the range of 24-30 year in (43.5%), <24 in (27.6%) and >30 years in (28.8%). 40 (16.2%) women have used HC for more than 5 years, 133(53.8%) for less than a year. The type of HC mostly used was progesterone-only formula in 130 (52.6%) of them and combined with estrogen in 117 (47.4%) of them. BC presented with breast lump only in 82.2% of the cases, with nipple discharge in 3.6%, and 30 (12.2%) of the patients complained of nipple symptoms only. However, the presenting symptom was bone pain in (2%). Positive family history was found in (35.6%). Surgical staging (13%) of the cases were considered as an advanced stage (stage III, IV). However, (61.5%) were found to have positive lymph nodes. In histopathology most diagnosis was invasive intra-ductal carcinoma (IDC) in 86.6%. The invasive medullary type was present in 8 cases (3.2%) and invasive Intra-lobular carcinoma (ILC) in 25 (10.1%). Immunohistochemistry showed the most common molecular subtype was luminal with 130 cases (52.6%) of Luminal A 60 cases (24.3%) Luminal B, Basal-like presented in 29 cases (11.7%) and HER2-positive in 28(11.3%). Basal-like subtype was associated with the age of menarche >13 (P-value>0.05) and more likely be ductal carcinoma.
Conclusions
Reproductive factors were associated with all subtypes; the strongest trends were with luminal-like subtypes especially luminal A subtype, however, these findings require further prospective studies to be confirmed.
Legal entity responsible for the study
Tripoli University Hospital.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.