S. Herrero (Majadahonda, Spain)

Hospital Universitario Puerta de Hierro - (INSALUD)

Author Of 1 Presentation

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143P - Fertility rates in Young Breast Cancer Patients (YBCP) and evolution. A new challenge

Abstract

Background

Breast cancer in Young patients (≤45 years) is about 15% of all new diagnosis. At Young age, fertility is often an important issue, especially when there is no offspring. The average age of the first time mothers is increasing in the last years in Spain. A 30% of the Spanish mothers have their first birth older than 35 years old. Pregnancy after breast cancer is still very uncommon.

Methods

A retrospective review of breast cancer patients under 45 years treated at the Oncology department in HUPHM in Madrid-SPAIN between 2009-2019 was performed. The number of pregnancies and births prior to the administration of any treatment was collected. The subgroup of nulliparous patients under 40 years of age who were candidates for fertility preservation was selected and these data have been analyzed.

Results

A total of 555 patients were analysed in the period selected. The number of pregnancies and births in our patients at the moment of diagnosis are described in the table.

<35 years 35-40 >40
No pregnancy 39% (22) 26% (37) 17% (61)
No births 35% (25) 30% (43) 19% (68)
No births or just one 60% (18) 37% (37) 27% (79)
A total of 74 patients under 40 years with no births were evaluated for fertility preservation. 14 patients (20%) were not candidates for fertility preservation due the need of a fast treatment or just local treatment. The selected 60 candidates were handle as follows: 20% refused preservation, 52% (31 Patients) performed oovocyte cryopreservation and the remaining 28% were not offered. Of the total, only 3 pregnancies were obtained, only one per transfer after preservation.

Conclusions

More than 30% of the YBCP ≤40 have no births at the moment of diagnosis. All of them should be referred to a fertility unit and informed about options. Women with just one child might be also informed about options. Very few pregnancies occur after breast cancer diagnosis and this a new challenge with a great area of improvement.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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