R. Cahyono (Yogyakarta, Indonesia)
Author Of 1 Presentation
139P - Association of Baseline Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios with Disease Progression in High-Risk Breast Cancer Patients
Abstract
Background
Incidence rates of breast cancer have continuously increased worldwide with higher proportion of mortality rates in developing countries. More than a third of breast cancer will develop distant metastases as the most attributable causes of mortality in malignancy. An economical but effective marker to estimate risk of disease progression might be very valuable in developing countries to improve surveillance.
Methods
A retrospective cohort study was performed in 1083 non-metastatic breast cancer patients to analyze the association of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with risk of breast cancer disease progression.
Results
Around three quarter of patients were diagnosed in stage III with median tumor size was 8 cm. Cut-off values were determined using Youden index resulting in threshold of 2.8 and 170 for NLR and PLR, respectively. At baseline analysis, higher NLRs were associated with skin and chest wall infiltration (p = 0.0001). Higher PLRs were associated with advanced stages (p = 0.03). After median follow up of 4.8 years, higher NLRs were associated with higher risks of disease progression (OR = 1.555; 95% CI: 1.206-2.005), shorter PFS (medians were 34.9 vs 53.5 months, P=0.001) and shorter time to develop distant metastases (66.6 vs 104.6 months, P=0.027).
Conclusions
High NLR values are associated with risks of breast cancer progression, shorter PFS, and shorter time to distant metastasis. Further larger or multicenter study is required to extend our understanding of NLR as potential marker for risk of breast cancer progression.
Legal entity responsible for the study
Sumadi Lukman Anwar, Universitas Gadjah Mada.
Funding
Universitas Gadjah Mada.
Disclosure
All authors have declared no conflicts of interest.
Presenter Of 1 Presentation
139P - Association of Baseline Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios with Disease Progression in High-Risk Breast Cancer Patients
Abstract
Background
Incidence rates of breast cancer have continuously increased worldwide with higher proportion of mortality rates in developing countries. More than a third of breast cancer will develop distant metastases as the most attributable causes of mortality in malignancy. An economical but effective marker to estimate risk of disease progression might be very valuable in developing countries to improve surveillance.
Methods
A retrospective cohort study was performed in 1083 non-metastatic breast cancer patients to analyze the association of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with risk of breast cancer disease progression.
Results
Around three quarter of patients were diagnosed in stage III with median tumor size was 8 cm. Cut-off values were determined using Youden index resulting in threshold of 2.8 and 170 for NLR and PLR, respectively. At baseline analysis, higher NLRs were associated with skin and chest wall infiltration (p = 0.0001). Higher PLRs were associated with advanced stages (p = 0.03). After median follow up of 4.8 years, higher NLRs were associated with higher risks of disease progression (OR = 1.555; 95% CI: 1.206-2.005), shorter PFS (medians were 34.9 vs 53.5 months, P=0.001) and shorter time to develop distant metastases (66.6 vs 104.6 months, P=0.027).
Conclusions
High NLR values are associated with risks of breast cancer progression, shorter PFS, and shorter time to distant metastasis. Further larger or multicenter study is required to extend our understanding of NLR as potential marker for risk of breast cancer progression.
Legal entity responsible for the study
Sumadi Lukman Anwar, Universitas Gadjah Mada.
Funding
Universitas Gadjah Mada.
Disclosure
All authors have declared no conflicts of interest.