A. Athman Omar (Alexandria, Egypt)
Author Of 1 Presentation
136P - The incidence and prognostic impact of obesity in young Egyptian breast cancer patients
Abstract
Background
The breast cancer (BC) incidence of young women in Africa and the Middle East is higher than that of the western population. Growing evidence shows a global increase in obesity incidence. Both obesity and young age are associated with poor survival in BC. Thus, it is relevant to address this question in this population.
Methods
We retrospectively reviewed 720 female BC patients ≤40 years who had the weight and height data in two centers in Alexandria – Egypt. The body mass index (BMI) was categorized according to WHO groups into underweight – UW (BMI 18.5 kg/m2), normal weight - NW (BMI ≥18.5 to < 25kg/m2), overweight – OW (BMI ≥25 to < 30kg/m2), obese – Ob (BMI >30 kg/m2). We determined the obesity incidence, clinicopathological features, and the impact of obesity on survival by Kaplan Meir and Cox regression.
Results
The median follow-up was 44 months (1 - 143). The BMI distribution was UW - 1.7% (12), NW - 11.1% (80), OW - 26.8% (193), Ob - 60.4% (435); more than 85% were Ob/OW. The median age in UW/NW, OW, and Ob was 34, 35, and 37 years, respectively. Ob patients were significantly older, p < 0.001. The mean tumor size was 3.4cm in UW/NW, 3.7cm – OW, and 3.7cm - Ob. The Ob had a significantly higher incidence of high nodal involvement (44%; p − 0.023), and significantly estrogen/progesterone negative (21.2%; p − 0.016). Ki-67 was higher in Ob (57.4%) and OW (74%) than UW/NW (50%); p – 0.222. The distant relapse rates were insignificantly higher in Ob - 25.7% and OW - 25.5% than UW/NW - 20.2%; p – 0.352. There were no significant differences in the mean disease-free survival (CI: 81 – 96; p-0.692) and the overall survival (CI:120 – 124; p-0.186). In the multivariate analysis and cox regression, obesity did not impact survival.
Conclusions
There is an alarmingly high incidence of Ob/OW among young Egyptian BC patients. Our results confirm that Ob patients have more aggressive features than UW/NW. Nevertheless, our results suggest that, despite the poor prognostic factors characteristics, higher BMI did not worsen the survivals.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Presenter Of 1 Presentation
136P - The incidence and prognostic impact of obesity in young Egyptian breast cancer patients
Abstract
Background
The breast cancer (BC) incidence of young women in Africa and the Middle East is higher than that of the western population. Growing evidence shows a global increase in obesity incidence. Both obesity and young age are associated with poor survival in BC. Thus, it is relevant to address this question in this population.
Methods
We retrospectively reviewed 720 female BC patients ≤40 years who had the weight and height data in two centers in Alexandria – Egypt. The body mass index (BMI) was categorized according to WHO groups into underweight – UW (BMI 18.5 kg/m2), normal weight - NW (BMI ≥18.5 to < 25kg/m2), overweight – OW (BMI ≥25 to < 30kg/m2), obese – Ob (BMI >30 kg/m2). We determined the obesity incidence, clinicopathological features, and the impact of obesity on survival by Kaplan Meir and Cox regression.
Results
The median follow-up was 44 months (1 - 143). The BMI distribution was UW - 1.7% (12), NW - 11.1% (80), OW - 26.8% (193), Ob - 60.4% (435); more than 85% were Ob/OW. The median age in UW/NW, OW, and Ob was 34, 35, and 37 years, respectively. Ob patients were significantly older, p < 0.001. The mean tumor size was 3.4cm in UW/NW, 3.7cm – OW, and 3.7cm - Ob. The Ob had a significantly higher incidence of high nodal involvement (44%; p − 0.023), and significantly estrogen/progesterone negative (21.2%; p − 0.016). Ki-67 was higher in Ob (57.4%) and OW (74%) than UW/NW (50%); p – 0.222. The distant relapse rates were insignificantly higher in Ob - 25.7% and OW - 25.5% than UW/NW - 20.2%; p – 0.352. There were no significant differences in the mean disease-free survival (CI: 81 – 96; p-0.692) and the overall survival (CI:120 – 124; p-0.186). In the multivariate analysis and cox regression, obesity did not impact survival.
Conclusions
There is an alarmingly high incidence of Ob/OW among young Egyptian BC patients. Our results confirm that Ob patients have more aggressive features than UW/NW. Nevertheless, our results suggest that, despite the poor prognostic factors characteristics, higher BMI did not worsen the survivals.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.