G. Pösteki (Izmit, Turkey)
Author Of 1 Presentation
164P - Usefulness of Positron Emission Tomography for Determination of Axillary Metastasis of Breast Cancer
Abstract
Background
Breast cancer is one of the most common cancer types for women worldwide. Metastatic status of axillary lymph nodes in breast cancer staging is very important. Axillary dissection and sentinel lymph node biopsies are currently the gold standard methods for axillary evaluation. In this study, the use of positron emission tomography as an alternative or as an adjunct to invasive methods for the detection of axillary metastasis of breast cancer has been evaluated.
Methods
Axillary SUV (standard uptake value) values of the all patients were recorded. The prediction of lymph node metastasis with MSKCC nomograms was preoperatively performed for all patients. Nomogram data were taken as the age, the size of the mass according to the preoperative images, the location of the tumor, and the lymph vascular invasion status in the preoperative pathological specimen, the unifocality or multifocality feature, estrogen and progesterone receptor status. The probability of axillary involvement was calculated by entering these criteria to the MSKCC Breast Cancer nomogram.
Results
According to the ROC analysis, its sensitivity was calculated as 80.95%, specificity 88.89%, positive predictive value 97.1%, and negative predictive value 50%. The cut-off value for axillary SUVmax was 2.3. The comparison of MSKCC nomogram data with axilla PET/CT SUVmax value was done. In the correlation analysis, it was seen that the increase in the axillary SUVmax value was not statistically similar to the increase in the percentage of the nomogram (p = 0,061). With correlation analysis, comparison of ER positivity and axillary SUVmax value was found to be insignificant (true r = -0.157, p = 0.270). (code r = -260, p = 0.065). There was significant and inverse difference between PR and axillary SUVmax values (true r= -0,285, p=0,043). (code r= -0.302, p = 0,031).
Conclusions
Today, use of PET/CT in the axillary evaluation of breast cancer is among the promising non-invasive methods. Its usability can be evaluated in new nomograms to be developed in the future. Its reliability may increase with new and sophisticated developments in the future due to advances in techniques. Unfortunately, its reliability alone is currently debatable.
Legal entity responsible for the study
Gökhan Pösteki.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Presenter Of 1 Presentation
164P - Usefulness of Positron Emission Tomography for Determination of Axillary Metastasis of Breast Cancer
Abstract
Background
Breast cancer is one of the most common cancer types for women worldwide. Metastatic status of axillary lymph nodes in breast cancer staging is very important. Axillary dissection and sentinel lymph node biopsies are currently the gold standard methods for axillary evaluation. In this study, the use of positron emission tomography as an alternative or as an adjunct to invasive methods for the detection of axillary metastasis of breast cancer has been evaluated.
Methods
Axillary SUV (standard uptake value) values of the all patients were recorded. The prediction of lymph node metastasis with MSKCC nomograms was preoperatively performed for all patients. Nomogram data were taken as the age, the size of the mass according to the preoperative images, the location of the tumor, and the lymph vascular invasion status in the preoperative pathological specimen, the unifocality or multifocality feature, estrogen and progesterone receptor status. The probability of axillary involvement was calculated by entering these criteria to the MSKCC Breast Cancer nomogram.
Results
According to the ROC analysis, its sensitivity was calculated as 80.95%, specificity 88.89%, positive predictive value 97.1%, and negative predictive value 50%. The cut-off value for axillary SUVmax was 2.3. The comparison of MSKCC nomogram data with axilla PET/CT SUVmax value was done. In the correlation analysis, it was seen that the increase in the axillary SUVmax value was not statistically similar to the increase in the percentage of the nomogram (p = 0,061). With correlation analysis, comparison of ER positivity and axillary SUVmax value was found to be insignificant (true r = -0.157, p = 0.270). (code r = -260, p = 0.065). There was significant and inverse difference between PR and axillary SUVmax values (true r= -0,285, p=0,043). (code r= -0.302, p = 0,031).
Conclusions
Today, use of PET/CT in the axillary evaluation of breast cancer is among the promising non-invasive methods. Its usability can be evaluated in new nomograms to be developed in the future. Its reliability may increase with new and sophisticated developments in the future due to advances in techniques. Unfortunately, its reliability alone is currently debatable.
Legal entity responsible for the study
Gökhan Pösteki.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.