F. Tandy (Tangerang, Indonesia)
UPH - Pelita Harapan University - Faculty of MedicineAuthor Of 1 Presentation
79P - Targeted Intraoperative Radiotherapy vs External Beam Radiotherapy in Early-Stage Breast Cancer Patients: A Systematic Review and Meta-Analysis
Abstract
Background
Targeted Intraoperative Radiotherapy (TARGIT) involves the precise delivery of a large dose of ionizing radiation to the tumor during surgery. TARGIT has emerged as an alternative to Breast External Radiotherapy (EBRT) for women with early breast cancer. However, its efficacy compared to EBRT remain unclear. This systematic review and meta-analysis aimed to evaluate the effectiveness of TARGIT compared to EBRT.
Methods
We searched PubMed, PMC, Science Direct, Google Scholar, and Europe PMC, on January 31st, 2021 using a combination of keywords associated with TARGIT, EBRT, and Breast Cancer concerning their survival rate based on Overall Survival (OS), Mastectomy Free Survival (MFS), Distant Disease-Free Survival (DDFS), and Local Recurrence Free Survival (LRFS). Publications included are limited to English manuscripts with observational design study that were published in the past 10 years. Patients with an incomplete personal or medical information were excluded from this review. All included studies were reviewed by all 6 authors. The quality of each included study was assessed using either the Newcastle-Ottawa Scale (NOS) or Jadad Score and GRADE.
Results
We included a total of 7 studies consisting of 110.532 breast cancer patients. Based on NOS, 3 studies showed good quality. Based on Jadad, 3 studies were good in quality while 1 study was fair. Based on GRADE, these studies were moderate in quality as there was a largely consistent and precise outcome with minimal publication bias. The association of TARGIT and EBRT were found in all included studies. Six studies showed that there is no significant difference between the two groups. However, one study showed that TARGIT was an effective alternative to EBRT. Pooled analysis showed that statistically TARGIT is associated with better OS (HR = 0.96; 95% CI, 0.95 - 0.97; p < 0.00001), MFS (HR = 0.93; 95% CI, 0.77-1.12; p = 0.44), DDFS (HR = 0.92; 95% CI, 0.76-1.12; p = 0.41), and LRFS (HR = 0.99; 95% CI, 0.83-1.17; p = 0,89) when compared with EBRT.
Conclusions
There is no significant difference in survival rate between TARGIT and EBRT. Further reliable research is needed.
Legal entity responsible for the study
Audrey Hadisurya.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.