F. Kraja (Tirana, Albania)
Author Of 1 Presentation
118P - Determinants of timing to metastasis in breast cancer patients in Albania
Abstract
Background
Development of metastasis in patients with breast cancer (BC) is the most important negative prognostic factor. The prognostic factors and their impact in the timing of distant metastasis has been the focus of different studies. The purpose of the study was to identify the risk factors for distant metastasis in Albanian breast cancer patients and their correlation with time to metastasis.
Methods
We retrospectively analyzed the data of 670 patients diagnosed with nonmetastatic invasive breast cancer from 2008 to 2016 in our clinic. Patients’ age at diagnosis, primary tumour stage, histopathology type, lymph node status, BC laterality and time to first metastases (TTM) were evaluated to identify the risk factors and timing for distant metastasis. Pearson's correlations, logistic regression, χ2 tests, Kruskal Wallis Tests, Mann-Whitney U test were used. Age-adjusted models were conducted. Statistical analysis was done using SPSS version 26 (SPSS, Chicago, IL).
Results
The patients’ mean age was 53.7± 10.9 years (range 28-84 years). Median follow up was 43 ± 28 months. From 670 patients with BC, 159 patients (23.7%) developed metastatic disease. Mean time to metastasis was 23 months (95% CI 19-28). An inverse correlation was found between age and TTM (r=-0.136, 0=0.087). According to localization, left breast cancer was observed in 332 patients (49.6%), right BC in 334 patients (49.9%) and only 4 patients (0.6%) had bilateral BC. Distant metastases were found more frequently in left laterality than right laterality (53,8 % vs 46.2%). Upon age-adjusted and multivariable adjustment for all covariates, factors associated with shorter TTM were the tumor stage at the diagnosis (p=0.004), nodal status (p=0.039) and histopathology type (p=0.008). No significant correlation was found according to tumor grade (p=0.800). TTM was shorter but not statistically significant in left BC compared with right BC [20.6 months (95% CI 15.5-25.7) vs 27.3 months (95% CI 20.8-33.7), p=0.126].
Conclusions
Our data showed that tumor stage, nodal status and histopathology type at time of the diagnosis are significant prognostic factors associated with shorter TTM. Further investigation should be focused on the impact of BC laterality as a possible prognostic factor in TTM.
Legal entity responsible for the study
Fatjona Kraja.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Presenter Of 1 Presentation
118P - Determinants of timing to metastasis in breast cancer patients in Albania
Abstract
Background
Development of metastasis in patients with breast cancer (BC) is the most important negative prognostic factor. The prognostic factors and their impact in the timing of distant metastasis has been the focus of different studies. The purpose of the study was to identify the risk factors for distant metastasis in Albanian breast cancer patients and their correlation with time to metastasis.
Methods
We retrospectively analyzed the data of 670 patients diagnosed with nonmetastatic invasive breast cancer from 2008 to 2016 in our clinic. Patients’ age at diagnosis, primary tumour stage, histopathology type, lymph node status, BC laterality and time to first metastases (TTM) were evaluated to identify the risk factors and timing for distant metastasis. Pearson's correlations, logistic regression, χ2 tests, Kruskal Wallis Tests, Mann-Whitney U test were used. Age-adjusted models were conducted. Statistical analysis was done using SPSS version 26 (SPSS, Chicago, IL).
Results
The patients’ mean age was 53.7± 10.9 years (range 28-84 years). Median follow up was 43 ± 28 months. From 670 patients with BC, 159 patients (23.7%) developed metastatic disease. Mean time to metastasis was 23 months (95% CI 19-28). An inverse correlation was found between age and TTM (r=-0.136, 0=0.087). According to localization, left breast cancer was observed in 332 patients (49.6%), right BC in 334 patients (49.9%) and only 4 patients (0.6%) had bilateral BC. Distant metastases were found more frequently in left laterality than right laterality (53,8 % vs 46.2%). Upon age-adjusted and multivariable adjustment for all covariates, factors associated with shorter TTM were the tumor stage at the diagnosis (p=0.004), nodal status (p=0.039) and histopathology type (p=0.008). No significant correlation was found according to tumor grade (p=0.800). TTM was shorter but not statistically significant in left BC compared with right BC [20.6 months (95% CI 15.5-25.7) vs 27.3 months (95% CI 20.8-33.7), p=0.126].
Conclusions
Our data showed that tumor stage, nodal status and histopathology type at time of the diagnosis are significant prognostic factors associated with shorter TTM. Further investigation should be focused on the impact of BC laterality as a possible prognostic factor in TTM.
Legal entity responsible for the study
Fatjona Kraja.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.