U. St.hilaire (Berlin, Germany)
St. Gertrauden-KrankenhausAuthor Of 1 Presentation
166P - Breast cancer at the age of 90 and above
Abstract
Background
The elderly population in Germany is increasing, which results in more frequent first diagnosis of breast cancer in patients at age 90 and above. Evidence about tumor characteristics is very limited and often filled in as established.
Methods
A retrospective systematic analysis of the data collection of the breast cancer centre of “Sankt-Gertrauden-Hospital”, Berlin, Germany from 2003 to 2019 (17 years) was performed considering the patients of age 90 and above at first diagnosis of breast cancer.
Results
In total we identified 58 patients with histologically confirmed first diagnosis of breast cancer at age 90 and above, on average, the patients were 92.9 years old. 8 patients (14.3%) were diagnosed with primary metastases, 29 (51.8%) were staged M0, the others declined or were just not checked. The most common type was the invasive ductal carcinoma (76%) meanwhile invasive lobular carcinoma was demonstrated in 12%. Regarding the grading of the tumors G1 equalled 7.4%, while G2 and G3 showed 64.8% and 27.8%, respectively. Hormone receptor-positive tumours were most frequent with 94.8%. Her2 positivity was expectedly low with only 7.3% out of 56 patients tested. In view of the comorbidities it was noticed that a patient had three relevant diagnoses on average, whereupon two-thirds were cardiovascular and lung diseases. 64.3% had an operation on their breast, 30.4% received surgery on axillary lymph nodes. Mastectomies and breast-preserving therapies were conducted about equally, however a sentinel lymph node technique was only performed on 23.5% of the overall lymph node surgeries. 28.3 % got the recommendation for radiotherapy. A total of 46 patients were recommended endocrine therapy. 36.2% out of 58 patients were proposed primary endocrine therapy with no further surgical treatment. In 51.8% of the cases the therapeutic recommendations also included antiresorptive therapy despite their higher age. Chemotherapy as well as antibody-therapy were only once respectively considered a feasible option.
Conclusions
Not much is known about breast cancer in the 90-and.above age group. Our analysis shows that there are patients with primary metastatic breast cancer more frequently but less frequently G1 and Her2 positive tumors among these patients. Geriatric oncology's task is to develop therapeutic concepts for such patients.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.