M. Mori De Santiago (Las Palmas de Gran Canaria, Spain)
Hospital Universitario de Gran Canaria Dr. NegrinAuthor Of 1 Presentation
- D. Aguiar Bujanda (Las Palmas de Gran Canaria, Spain)
- L. Ros Sanjuan (Las Palmas de Gran Canaria, Spain)
- D. Perez Cabrera (Las Palmas de Gran Canaria, Spain)
- L. Croissier Sanchez (Las Palmas de Gran Canaria, Spain)
- M. Mori De Santiago (Las Palmas de Gran Canaria, Spain)
- M. Hernandez Sosa (Las Palmas de Gran Canaria, Spain)
- A. Vargas Prado (Las Palmas de Gran Canaria, Spain)
- S. Galvan Ruiz (Las Palmas de Gran Canaria, Spain)
- C. Antonilli Perez (Las Palmas de Gran Canaria, Spain)
- R. Ten Benajes (Las Palmas de Gran Canaria, Spain)
- B. Fox (Las Palmas de Gran Canaria, Spain)
- R. Martinez Garcia-Cervantes (Las Palmas de Gran Canaria, Spain)
- G. Rubio Romero (Las Palmas de Gran Canaria, Spain)
- R. Hanselmann (Las Palmas de Gran Canaria, Spain)
- S. Saura Grau (Las Palmas de Gran Canaria, Spain)
71P - Impact of body mass index (BMI) on pathological complete response (pCR) and survival of breast cancer (BC) patients receiving neoadjuvant chemotherapy (NAC)
Abstract
Background
High BMI is generally considered a poor prognostic factor in BC. However, its association with pCR and survival after NAC is still controversial. The aim of this study was to evaluate the prognostic impact of BMI on clinical outcomes in BC patients undergoing NAC.
Methods
Retrospective review of 314 patients with BC who received NAC from 2010 to 2018 at the Department of Medical Oncology, Hospital Universitario de Gran Canaria Dr Negrin (Spain). Patients were categorized as underweight/normal weight (UW/NW) (BMI<25) or overweight/obese (OW/OB) (BMI>=25). Logistic regression analysis was used to evaluate the associations between BMI, classic clinical-pathological prognostic factors and pCR (defined as ypT0/Tis ypN0). Event-free survival (EFS) and overall survival (OS) were estimated using the Kaplan-Meier method, and associations with prognostic factors were obtained using the Cox proportional hazards regression analysis.
Results
Median BMI was 26.0 kg/cm2. In total, 122 patients were UW/NW and 192 were OW/OB. A pCR was obtained in 23.4% of patients. The pCR did not differ between groups (20% for patients with BMI<25 and 25% for those with BMI>=25, p=0.271). Multivariate analysis revealed that only hormonal receptors negative, HER2 positive, and cT1-2 were found to be independent predictor factors for pCR. Non-significant differences in EFS or OS were observed between the two baseline BMI categories. Multivariate analysis confirmed tumor grade G3 and absence of pCR as independent prognostic factors associated with a worse EFS. Factors associated with a worse OS in the multivariate analysis were cT3-4, hormone receptors negative, and no-pCR after NAC.
Conclusions
In our experience, BMI was not associated with clinical outcomes (pCR, EFS and OS) in BC patients receiving NAC. Classic pathological features of the tumor are the main prognostic factors related with pCR and survival. Achieving pCR after NAC is the most consistent factor associated with EFS and OS. Prospective studies are needed to determine the exact role of BMI in this setting.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.