V. Degennaro (Port-au-Prince, Haiti)
Innovating Health International Cancer ProgramAuthor Of 1 Presentation
161P - Impact of HIV infection on mortality rate and overall survival of women with breast cancer in a Haitian cancer clinic.
Abstract
Background
The prevalence of HIV infection in Haiti is around 2%. Patients with HIV infection are more likely to develop neoplasms than HIV-negative individuals and have a poorer outcome. This main objective of this study was to determine the impact of HIV infection on mortality and overall survival of women with breast cancer.
Methods
A four-year retrospective study was conducted in the cancer program of Innovating Health International (IHI). We included all women with breast and a known HIV status enrolled from January 1st, 2016 to December 31st, 2019. Date of admission, age, cancer stage, antiretroviral therapy status for HIV-infected patients, outcome as of December 31st, 2019 and date of death were the main variables selected for the chart review. We sought to evaluate if HIV infection was associated with increased mortality rate and reduced survival in our setting.
Results
Of the 1039 women with breast cancer managed during the study period, 512 (49.3%) had a known HIV status. Sixteen of them (3.1%) were HIV-positive. Their mean age was 43.4 years [range: 34-59] versus 49.6 years [range: 27-92] for the HIV-negative patients (p = 0.04). 50% of the women were already known HIV-positive before their admission to cancer care and on antiretroviral therapy. HIV-positive women with breast cancer were more likely to have stage IV disease (Odds ratio (OR)= 2.9 [95% CI, 1.1 – 7.8], p = 0.03) or die (OR=1.1 [95% CI, 0.3 – 3.8], p=0.8) than HIV-negative ones. The mortality rate was 25% [95% CI, 7.3% – 52.4%] versus 26.6% [95% CI, 22.8% – 30.7%] for the HIV-negative women (p=0.82). Median survival was not yet reached for both subpopulations, and mean survival was 17.2 months for HIV-positive patients versus 34.3 months for HIV-negative ones (Logrank p=0.25).
Conclusions
Women with breast cancer and HIV infection were significantly younger and more likely to have metastatic disease than HIV-negative ones. HIV infection was not associated with reduced mortality rate or overall survival in our cohort.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.