C. Corbacho (Majadahonda, Spain)

Hospital Universitario Puerta de Hierro - (INSALUD)

Author Of 1 Presentation

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175P - Tumor biology in Young Breast Cancer Patients (YBCP). A different disease?

Abstract

Background

Breast cancer in Young patients has been related to a more aggressive tumor biology in some studies, due to a more frequent triple negative disease, grade III or vascular/lymphatic invasion. Early age at the time of breast cancer diagnosis has emerged worldwide as an independent factor associated with an increased risk of relapse and death regardless of the treatment administered with some controversies in the cut-off age (40 vs 45).

Methods

We have performed a retrospective analysis of YBCP (≤45 years) treated at the Oncology Department in HUPHM in Madrid-Spain, diagnosed with infiltrating breast cancer between 2009-2019. All data from the pathology and immunohistochemical report were collected and analyzed. We have examined the difference between subtypes and pathological characteristics according to age (<40 and ≥40-45).

Results

From a total of 600 YBCP analyzed, we identified 559 with infiltrating breast carcinoma of which we have a pathological report. The differences according to age are shown below:

<40 ≥40-45 Global population p value
Histology Ductal Lobulillar Other 89% 5% 6% 82% 11% 7% 84% 9% 7% p = 0,1
Grade I II III Unknown 18% 45% 32% 5% 21% 47% 28% 4% 20% 46% 30% 4% p = 0,6
Multicentricity 26% 33% 31% p = 0,09
Histologic Subtypes: Triple Negative HR+ HER2- HR+ HER2+ HR-HER2+ 12% 70% 13% 5% 12% 71% 12% 5% 12% 71% 12% 5% p = 0,9
Ki-67 < 14 ≥ 15 32% 68% 38% 62% 36% 64% p = 0,18
Hormone Receptor ER-/PR- ER+/PR- ER-/PR+ ER+/PR+ 17% 5% 2% 76% 16% 6% 2% 76% 16% 6% 2% 76% p = 0,9
Lymphovascular invasion 35% 35% 35% p = 0,9
Perineural invasion 14% 13% 13% p = 0,8

Conclusions

Most of the tumours were invasive ductal carcinoma, just 20% were grade I, only 12% triple negative tumors, 64% of the tumors had a high ki-67, 83% were hormone receptor positive (76% of them positive for both receptors). Lymphovascular and perineural invasion was present in 35% and 13% respectively. No significant differences were found according to age, with a similar distribution in the different subtypes and prognostic features.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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