Moderator of 1 Session
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O064 - AUTOIMMUNE AUTONOMIC DYSFUNCTION SYNDROMES: COMPLEX REGIONAL PAIN SYNDROME, FIBROMYALGIA, CHRONIC FATIGUE SYNDROME, SILICONE BREAST IMPLANTS RELATED SYMPTOMS, AND POST COVID SYNDROME (ID 199)
Abstract
Background and Aims
The pathophysiological mechanism of the clinical symptomatology in chronic disorders such as complex regional pain syndrome, fibromyalgia, chronic fatigue syndrome, silicone breast implants related symptoms, and post COVID syndrome have not been clearly defined yet. The course of the pain in part of the syndromes, the absence of evident tissue damage, and the predominant autonomic dysfunction features are shared similarities between them.
Methods
The production of autoantibodies following a trigger in these syndromes were previously described. For instance, trauma as a trigger of complex regional pain syndrome, infectious agents in fibromyalgia, chronic fatigue syndrome, and the post COVID syndrome, and the immune stimulation by silicone in women with breast implants.
Results
The autoantibodies produced, were shown to be directed against the autonomic nervous system receptors leading to the amplification of the perception of pain and to various clinical symptoms seen in patients diagnosed with these syndromes. Therefore, autoantibodies targeting the autonomic nervous system resulting in autonomic dysfunction is probably the most comprehensive explanation of the pathophysiology of the disorders mentioned.
Conclusions
We introduce hereby a new notion uniting complex regional pain syndrome, fibromyalgia, chronic fatigue syndrome, silicone breast implants related symptoms, and post COVID syndrome, namely “autoimmune autonomic dysfunction syndromes”. We believe that our notion is more precise in classifying the syndromes under one title, due to its etiological, pathophysiological, and clinical properties. The suggested term would facilitate both lab and clinical studies aimed for better diagnosis and treatment options for the syndromes included.