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O028 - ASSOCIATION BETWEEN COVID-19 VACCINATION AND AUTOIMMUNE BULLOUS DISEASES: A SYSTEMATIC REVIEW (ID 772)
Abstract
Background and Aims
An association between COVID-19 vaccination and autoimmune bullous diseases (AIBDs) has been suggested, but no systematic evaluation exists to corroborate this assumption.
Methods
A systematic literature review focusing on this potential link was performed.
Results
Electronic searches using PubMed from inception to February 2022 identified 30 reports meeting predetermined inclusion and exclusion criteria. Among 932 immunized individuals, patients either presented clinically with de novo AIBDs (n = 53; 5.7%) or had a flare/worsening of pre-existing AIBDs (n = 91; 9.7%) after vaccination, whereas vaccination did not negatively influence the clinical course in 788 (84.5%) patients. The reported time between receiving the first or second dose of the vaccine and manifestation of AIBDs ranged between 1 day and 6 weeks, with some patients experiencing aggravation of their AIBD symptoms after the second dose. The clinical courses of post-vaccinal AIBDs were mostly well controlled with conventional immunosuppressive therapy.
Conclusions
While causality between COVID-19 vaccination and AIBDs remains unproven and should not affect present vaccination recommendations for this group of patients, raised awareness and timely recognition of rare post-SARS-CoV-2-vaccinal cases would be important for their optimal management.