Abstract Body

Systemic autoimmune thrombosis or antiphospholipid syndrome is a treatable cause of miscarriages and
of recurrent spontaneous pre-embryonic and embryonic abortions. Three groups of management could
be identified for antiphospholipid syndrome. Low doses of aspirin and low-molecular-weight heparins
are recommended for treatment of this disorder. The use of glucocorticoids and intravenous immunoglobulins
can be justified in special cases. Strict control and an interdisciplinary approach during treatment of these
patients is mandatory. Inflammatory autoimmune mechanisms in the pathophysiology of obstetric
antiphospholipid syndrome and anti-inflammatory and immunomodulatory mechanisms of drug action
should be considered during individual treatment scheme selection.