Presenter of 2 Presentations
O081 - PARANEOPLASTIC SYNDROMES MASQUERADING AS AUTOIMMUNE DISEASE (ID 705)
Abstract
Background and Aims
Background: Paraneoplastic syndromes may present as autoimmune diseases with atypical presentations in the elderly, or as an exacerbation following a prolonged remission.
Aim: Present a descriptive narrative of a case series of autoimmune disease as the first manifestation of malignancy
Methods
Methods: Patient cases were retrieved from the Wolfson Medical Center database. We reviewed the files for a new onset or flare of autoimmune disease, time to diagnosis and type of malignancy, and survival.
Results
Results: One patient presented with a flare of cicatrial pemphigus following a long-standing remission. She was treated with prednisone with a good response. Some months later, she complained of weight loss, and a whole-body CT revealed lung cancer. The patient died about 18 months from the flare. The second patient presented with a mild flare of SLE after years of remission. Breast cancer was soon diagnosed afterwards. Two years later, following oncologic remission, a second flare again proved to be an oncologic relapse. A third patient was diagnosed with atypical scleroderma sine scleroderma. Initially, a malignancy was not detected. Upon repeated CT, lung cancer was detected 6 months later. The last patient was hospitalized and diagnosed as hypereosinophilic syndrome. The patient only complained of weakness. A whole body CT revealed lung cancer.
Conclusions
Conclusion: A flare after years of remission or an atypical onset of autoimmune disease can be a paraneoplastic syndrome. Close surveillance and repeated imaging are important. Early awareness and detection of a malignancy may be lifesaving.
O094 - HIV AND AUTOIMMUNITY- A REVIEW OF LITERATURE (ID 708)
Abstract
Background and Aims
Background: Autoimmune diseases in the immune deficient patient with HIV infection or AIDS remain fascinating as both are related to immune dysfunction. The spectrum of reported autoimmune phenomena in HIV infected patients is increasing, especially in AIDS patients that receive highly active anti-retroviral therapy (HAART).
Aims: Rheumatic manifestations due to initial infection of the HIV virus have decreased with the advent of HAART, although the prevalence of autoimmune diseases due to immune restoration inflammatory syndrome (IRIS) has increased.
Methods
Methods: We searched the English language medical literature from the PubMed database published from 2002 to 2021 concerning various autoimmune diseases in HIV and AIDS patients.
Results
Results: Over 300 HIV/AIDS patients with various autoimmune diseases are described
Conclusions
Conclusion: This review will summarize the clinical findings of autoimmune disease in HIV patients through the progression of infection from HIV to AIDS to IRIS.