Presenter of 3 Presentations
IN HONOUR OF LATE JORGE MARTINS: AN INTERNIST IN LOVED WITH AUTOIMMUNITY (ID 953)
COMORBIDITIES IN AUTOIMMUNE PATIENTS (ID 941)
O006 - RELATIONSHIP BETWEEN VITAMIN D RECEPTOR POLYMORPHISMS AND GUT MICROBIOME IN SYSTEMIC LUPUS ERYTHEMATOSUS AND MULTIPLE SCLEROSIS: A PILOT CROSS-SECTIONAL STUDY (ID 743)
Abstract
Background and Aims
Vitamin D receptor (VDR) polymorphisms have been implicated as significant contributors in microbiota variation from the general population and patients with specific disease entities, but not specifically in Systemic Lupus Erythematosus (SLE) or Multiple Sclerosis (MS)
Methods
Cross-sectional fecal microbiome sampling of SLE and MS patients at a University referral centre, from September 2019 to February 2020. Microbiome composition was obtained by NGS sequencing of the V4 region of the 16S rRNA gene region. VDR polymorphisms FokI and TaqI were assayed by real-time PCR.
Results
48 patients were enrolled (29 MS; 19 SLE). 37 (77%) were females; SLE and MS patients were characterized by high relative abundance of Bacteroidota and Firmicutes, as has often been reported for the general population. There was no difference in microbiome composition between both disease groups. In both SLE and MS, FokI polymorphisms were not associated with abundance of specific phyla of fecal microbiome (Table 1 and 2). In MS, but not in SLE, TaqI CC genotype was associated with higher relative abundance of Proteobacteria (p-value= 0,025) (Table 3 and 4). Firmicutes/Bacteroidota ratio were not associated with FokI and TaqI polymorphisms
Conclusions
VDR polymorphisms may be associated with specific fecal microbiota abundance in MS patients, but not SLE patients. These preliminary exploratory results should be further investigated