Centro Hospitalar Universitário do Porto e Centro Hospitalar Tamega e Sousa
Unidade de Imunologia Clinica. Consulta de doenças autoimunes
Carlos Vasconcelos is an Internal Medicine Specialist, with differentiation in the field of Clinical Immunology. In 1992, worked with Prof. Yehuda Shoenfeld in the TelAviv University, in the areas of immunology and rheumatology. He received his PhD in 2007 with the thesis “Epidemiology of Systemic Lupus Erythematosus in the north of Portugal”. He was the founder of UIC - Unidade de Imunologia Clínica of Centro Hospitalar Universitário do Porto till 2016, when he retired from public functions; he is still working regularly pro bono in UIC. He is Professor of Medicine at the Medical School Instituto Biomédicas Abel Salazar, University of Porto. He is member of SLEuro, Euro-Lupus, Euro-Phospholipid, international Lupus Nephritis Terminology Advisory Group, American College of Rheumatology, Portuguese Immunology Society, Portuguese Internal Medicine Society and of the Consortium of Autoimmune Centers. He and his team participated in international projects as BIOLUPUS, PreciseSADs, T2T in SLE and EULAR Lupus task force. He was chair of the 8º European Lupus Meeting, Porto Abril 2011, and honorary president of the 11º Autoimmunity congress in Lisbon 2018. He received the first National prize of the Portuguese Internal Medicine in 2016.

Presenter of 3 Presentations

IN HONOUR OF LATE JORGE MARTINS: AN INTERNIST IN LOVED WITH AUTOIMMUNITY (ID 953)

Date
Tue, 28.02.2023
Session Time
14:30 - 16:30
Session Type
PARALLEL SESSIONS
Room
ALEXANDRA TRIANTI
Lecture Time
14:30 - 14:35

COMORBIDITIES IN AUTOIMMUNE PATIENTS (ID 941)

Date
Mon, 13.06.2022
Session Time
17:00 - 19:00
Session Type
PARALLEL SESSIONS
Room
NIKOS SKALKOTAS
Lecture Time
17:00 - 17:10

O006 - RELATIONSHIP BETWEEN VITAMIN D RECEPTOR POLYMORPHISMS AND GUT MICROBIOME IN SYSTEMIC LUPUS ERYTHEMATOSUS AND MULTIPLE SCLEROSIS: A PILOT CROSS-SECTIONAL STUDY (ID 743)

Date
Tue, 28.02.2023
Session Time
10:30 - 12:30
Session Type
PARALLEL SESSIONS
Room
ALEXANDRA TRIANTI
Lecture Time
12:20 - 12:30

Abstract

Background and Aims

Vitamin D receptor (VDR) polymorphisms have been implicated as significant contributors in microbiota variation from the general population and patients with specific disease entities, but not specifically in Systemic Lupus Erythematosus (SLE) or Multiple Sclerosis (MS)

Methods

Cross-sectional fecal microbiome sampling of SLE and MS patients at a University referral centre, from September 2019 to February 2020. Microbiome composition was obtained by NGS sequencing of the V4 region of the 16S rRNA gene region. VDR polymorphisms FokI and TaqI were assayed by real-time PCR.

Results

48 patients were enrolled (29 MS; 19 SLE). 37 (77%) were females; SLE and MS patients were characterized by high relative abundance of Bacteroidota and Firmicutes, as has often been reported for the general population. There was no difference in microbiome composition between both disease groups. In both SLE and MS, FokI polymorphisms were not associated with abundance of specific phyla of fecal microbiome (Table 1 and 2). In MS, but not in SLE, TaqI CC genotype was associated with higher relative abundance of Proteobacteria (p-value= 0,025) (Table 3 and 4). Firmicutes/Bacteroidota ratio were not associated with FokI and TaqI polymorphisms

 table1.png table 2.pngtable 3.pngtable4.png

Conclusions

VDR polymorphisms may be associated with specific fecal microbiota abundance in MS patients, but not SLE patients. These preliminary exploratory results should be further investigated

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