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O051 - LINKAGE OF ANTI-RO AND ANTI-LA SEROPOSITIVITY IN ADULTS WITH CARDIAC ARRHYTHMIAS: INSIGHTS FROM A LARGE CROSS-SECTIONAL STUDY (ID 54)
Abstract
Background and Aims
Anti-Ro/SSA(anti-Ro) and anti-La/SSB(anti-La) are autoantibodies from the IgG class, targeted against intracellular ribonucleoproteins. These antibodies are prevalent in several autoimmune diseases but are also relatively frequent in healthy adults. The arrhythmogenic effect of anti-Ro antibodies on the premature conductive system is well established, with substantial evidence demonstrating increased risk for congenital atrioventricular(AV)-block in neonates of seropositive mothers. Traditionally, adult cardiomyocytes were considered invulnerable to these effects, however recent reports begin to challenge this paradigm. Despite their wide distribution and their arrhythmogenic potential, to date there are no large-population studies conducted in seropositive healthy adults.Therefore, in the present study we aimed to perform the first large population-based study investigating the association between anti-Ro/La seropositivity to cardiac rhythm and conduction disturbances in healthy adults.
Methods
This a cross-sectional study based on the electronic-health-records of HMO in Israel. All subjects that were tested positive for anti-Ro/anti-La antibodies between the years 2002-2019 were included and were matched by age, gender, and place of residence, with controls. Sensitivity analyses was performed using propensity score matching.
Results
17,231 anti-Ro/La seropositive subjects and 84,368 controls were enrolled. Anti-Ro seropositive patients had higher rates of conduction disturbances (3% vs. 1.7%,p<0.001) and rhythm disturbances (10.5% vs. 7%,p<0.001). Patients which were positive for anti-La alone did not demonstrate a significant association with arrythmias. Multivariate logistic-regression-analysis had demonstrated an increased risk for cardiac conduction disturbances (OR=1.43,95%CI 1.25-1.64,p<0.001), as well as for cardiac arrhythmias (OR=1.47,95%CI 1.37-1.57,p<0.001) among anti-RO seropositive patients.
Conclusions
Anti-Ro seropositivity is positively associated with cardiac rhythm and conduction disturbances in healthy adults.