Presenter of 1 Presentation
O102 - SURVIVAL OF PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES (ID 10)
Abstract
Background and Aims
Idiopathic inflammatory myopathies (IIMs) are rare systemic diseases associated with significant morbidity and mortality. The aim of our observational study was to estimate for the first time the survival of IIM patients in Slovenia.
Methods
We included IIM patients diagnosed between Jan/2005 and Dec/2020, and followed at two secondary/tertiary rheumatology centers in the country. To study survival the censor date of April 14, 2021, was set. Kaplan–Meier analysis and standardized mortality ratio (SMR) were plotted using data of age and sex matched Slovenian population as a reference. Cox proportional hazards regression analysis was used to study prognostic factors for death.
Results
During the 16-year observation period, we identified 217 IIM patients. During follow up 65 (30.0%) patients died. One- and five-year survival rate was 88.9% and 75.5%, respectively. In the first year following IIM diagnosis the SMR was nearly 7-fold higher compared to the matched general population (SMR 6.88 (95%CI 4.41–10.24)) and remained higher also during the following 4 years. However, when excluding IIM patients with cancer, the survival outcome was, except in the first year after IIM diagnosis (SMR 5.55 (95%CI 3.10 – 9.15)), comparable to matched general population. In addition to cancer (HR 3.71 (95% CI 2.18–6.04)), cardiac involvement (HR 2.18 (95% CI 1.07 – 4.45)), fever (HR 2.13 (95% CI 1.13 – 4.03)) and age (HR 1.07 (95% CI 1.04 – 1.09)) emerged as prognostic factors associated with death.
Conclusions
The overall survival of IIM patients was worse compared to matched general population. Cancer was the leading cause of death in our cohort.