Aristo Vodjani, United States of America

Immunosciences Lab., Inc. Laboratory
Aristo Vojdani, PhD, MSc, CLS, obtained his MSc and PhD in the fields of microbiology and clinical immunology from Bar-Ilan University in Israel with postdoctoral studies in comparative immunology at UCLA and tumor immunology at Charles Drew/UCLA School of Medicine and Science. He is an Adjunct Associate Professor in the Dept. of Preventive Medicine at Loma Linda University in California, and an Adjunct Professor at the Lincoln College of Professional, Graduate and Continuing Education at the National University of Health Sciences. His ongoing research focuses on the role of environmental triggers in complex diseases. Dr. Vojdani's research has resulted in the development of more than 300 antibody assays for the detection of autoimmune disorders and other diseases. He holds 17 US patents for laboratory assessments of immune disorders associated with the brain and gut, has published over 180 articles in magazines and scientific journals, and published the book "Neuroimmunity and the Brain-Gut Connection" with Nova Science Publishers. His latest book is “Food-Associated Autoimmunities: When Food Breaks Your Immune System,” available from Amazon and Barnes & Noble. He is the CEO and Technical Director of Immunosciences Lab in Los Angeles, California, and is also the Chief Scientific Advisor for Cyrex Labs in Phoenix, Arizona. Dr. Vojdani sits on the editorial board of the Journal of Alzheimer’s Disease and five other scientific journals. Over the years he has received many awards and honors including the Herbert J. Rinkel Award from the American Academy of Environmental Medicine, the Linus Pauling, PhD Award from the American College for Advancement in Medicine, the F. R. Carrick Research Institute’s Lifetime Achievement Award, and the Personalized Lifestyle Medicine Institute Lifetime Achievement Award.

Presenter of 1 Presentation

 Conference Calendar

CONTRIBUTION OF THE ADJUVANT ACTIVITY OF ALUMINUM TO AUTOIMMUNITY

Session Name
PS22 -ASIA SYNDROME, BREAST IMPLANTS AND AUTOIMMUNITY
Session Type
PARALLEL SESSIONS
Date
30.05.2021, Sunday
Session Time
10:00 - 12:00
Room
HALL D
Lecture Time
10:50 - 11:00
Presenter
Session Icon
Pre Recorded

Abstract

Background and Aims

Introduction: Aluminum salts containing adjuvants, with or without HSA, have been used in vaccines for more than 70 years. The addition of aluminum to viral or bacterial antigens results in neoantigen formation. Increased consumption of processed foods is a major source of aluminum exposure, which makes the gut the main target of inflammation and autoimmunity. About 1% of ingested aluminum accumulates in the skeletal system and the brain, where aluminum induces the cross-linking of Aβ-42 peptide and the formation of amyloid aggregates that is observed in Alzheimer’s disease.

Methods

We used ELISA methodology to measure IgG antibody against HSA-bound aluminum compounds in 94 different sera from healthy controls and patients with rheumatoid arthritis (RA), Crohn’s, celiac, mixed connective tissue and Alzheimer’s disease.

Results

Our results demonstrated that in control groups the mean OD of aluminum-HSA IgG antibody was 0.58. In comparison, the mean level of aluminum-HSA antibody was 0.96 for Crohn’s , 1.0 for celiac, 1.25 for Alzheimer’s, 0.61 for RA, and 0.57 for mixed connective tissue disease. The differences in antibody level against aluminum-HSA were highly significant for Crohn’s, celiac and Alzheimer’s disease, less significant for RA, and insignificant for mixed connective tissue disease.

Conclusions

We demonstrate extensive IgG reactivity against aluminum bound to HSA in the sera of patients with Crohn’s, celiac and Alzheimer’s disease, to a lesser degree with RA, and not in mixed connective tissue disease. We concluded that aluminum ingestion and absorption from the GI tract contributes to some of these diseases.

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